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Background: Parkinson's Disease (PD) is a neurodegenerative disorder with prodromal gastrointestinal (GI) issues often emerging decades before motor symptoms. Pathologically, PD can be driven by accumulation of misfolded alpha synuclein (aSyn) protein in the brain and periphery, including the GI tract. Disease epidemiology differs by sex, with men twice as likely to develop PD.
View Article and Find Full Text PDFAnti-mitochondrial antibodies in systemic sclerosis target enteric neurons and are associated with GI dysmotility.
medRxiv
November 2024
Division of Gastroenterology, Dept of Medicine, Beth Israel Deaconess Medical Center, United States.
Background: Most patients with systemic sclerosis (SSc) experience gastrointestinal (GI) dysmotility. The enteric nervous system (ENS) regulates GI motility, and its dysfunction causes dysmotility. A subset of SSc patients harbor autoantibodies against the M2 mitochondrial antigen (AMA).
View Article and Find Full Text PDFTyphoid & paratyphoid vaccine development in the laboratory: a review & in-country experience.
Indian J Med Res
December 2024
ICMR-National Institute of Occupational Health, Ahmedabad, Gujarat, India.
Enteric fever is caused by the infection of Gram-negative bacteria, Salmonella enterica serovar Typhi and Salmonella enterica serovar Paratyphi (S. Paratyphi) A, B and C, through contaminated food and water. The disease almost exclusively affects the populations living in low- and middle-income countries, with the World Health Organization Southeast Asian Region (WHO SEAR) having the highest endemicity.
View Article and Find Full Text PDFSevere Acute Transverse Myelitis With a Rapid Progression in an Infant.
Cureus
October 2024
Pediatric Intensive Care Unit, Hospital Pediátrico, Unidade Local de Saúde de Coimbra, Coimbra, PRT.
Article Synopsis
- Acute transverse myelitis (ATM) is a rare spinal cord inflammation that can result from infections or other systemic diseases, often leading to motor and sensory dysfunction.
- A case report describes a 10-month-old boy with severe ATM likely caused by enteritis, who developed rapid motor deficits and required extended care in a pediatric ICU, including mechanical ventilation.
- Despite various treatments, the patient faced prolonged recovery and significant neurological deficits, underscoring the need for comprehensive care and rehabilitation in managing severe ATM cases.
Objective: The current study evaluated the greenhouse gas (GHG) emissions of dairy cattle through the Global Livestock Environmental Assessment Model model and illustrated potential mitigation strategies by modifying nutrition interventions.
Materials And Methods: A semi-structural questionnaire was developed to calculate dairy animal GHG emissions. This study comprised 40 farmers from four districts: river basin (Pabna), drought-prone (Chapainobabganj), floodplain (Nilphamari), and saline-prone (Sathkhira) areas.
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