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Rule-mediated connectivity in social-ecological-technological systems: A comparative network analysis of reservoir operation rules in Coyote Valley Dam (United States) and Ameghino Dam (Argentina).
J Environ Manage
January 2025
School of Sustainable Engineering and the Built Environment, Arizona State University, United States. Electronic address:
In the management of reservoirs, different forms of infrastructure (such as dams, hydropower units, information) are functionally interdependent and often managed by different types of actors to form a social-ecological-technological system. Such interdependence also occurs because institutions (understood as rules that guide and constrain actor behavior) exist to indicate how infrastructures should be managed. We apply institutional analysis and social network analysis to identify how functionally interdependent infrastructures and actors are connected by formal rules created to manage reservoir operations in Argentina (Ameghino Dam, Chubut) and the United States (Coyote Valley Dam, California).
View Article and Find Full Text PDFUL24 herpesvirus determinants of pathogenesis: Roles in virus-host interactions.
Virology
December 2024
Institut National de La Recherche Scientifique, Laval, Québec, Canada.
Members of the UL24 herpesvirus gene family are determinants of pathogenesis. The gene is widely conserved across the Orthoherpesviridae family, also commonly referred to as Herpesviridae. In this review, the impact of UL24 homologs on pathogenesis as studied with different model systems is presented, as well as mechanistic aspects related to the different roles of UL24 proteins in virus-host cell interactions.
View Article and Find Full Text PDFPDPN+ cancer-associated fibroblasts enhance gastric cancer angiogenesis via AKT/NF-κB activation and the CCL2-ACKR1 axis.
MedComm (2020)
January 2025
Department of Oncology Shanghai Medical College, Fudan University Shanghai China.
Cancer-associated fibroblasts (CAFs) are intrinsic components of the tumor microenvironment that promote cancer progression and metastasis. Through an unbiased integrated analysis of gastric tumor grade and stage, we identified a subset of proangiogenic CAFs characterized by high podoplanin (PDPN) expression, which are significantly enriched in metastatic lesions and secrete chemokine (CC-motif) ligand 2 (CCL2). Mechanistically, PDPN(+) CAFs enhance angiogenesis by activating the AKT/NF-κB signaling pathway.
View Article and Find Full Text PDFWhiA transcription factor provides feedback loop between translation and energy production in a genome-reduced bacterium.
Front Microbiol
December 2024
Scientific Research Institute of Systems Biology and Medicine, Moscow, Russia.
Introduction: WhiA is a conserved protein found in numerous bacteria. It consists of an HTH DNA-binding domain linked with a homing endonuclease (HEN) domain. WhiA is one of the most conserved transcription factors in reduced bacteria of the class Mollicutes.
View Article and Find Full Text PDFtRNA gene content, structure, and organization in the flowering plant lineage.
Front Plant Sci
December 2024
National Institute of Molecular Biology and Biotechnology, College of Science, University of the Philippines Diliman, Quezon City, Philippines.
Transfer RNAs (tRNAs) are noncoding RNAs involved in protein biosynthesis and have noncanonical roles in cellular metabolism, such as RNA silencing and the generation of transposable elements. Extensive tRNA gene duplications, modifications to mature tRNAs, and complex secondary and tertiary structures impede tRNA sequencing. As such, a comparative genomic analysis of complete tRNA sets is an alternative to understanding the evolutionary processes that gave rise to the extant tRNA sets.
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