The aim of the present study was to estimate the concentration of Cu, Zn, Mg, Ca in the following tissues: brain, heart, lung, liver, kidney and femoral muscles in conditions of experimentally induced hyperthyreosis. In general, in state of hyperthyreosis the concentration of all elements was considerably higher compared to euthyreosis. However, there are a few exceptions. Liver and heart tissue possessed higher concentration of Zn and Cu and kidney of Cu in euthyreosis.
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Ann Intern Med
January 2025
Durham VA Health Care System, Durham; and Division of General Internal Medicine, Department of Medicine, Duke University School of Medicine, Durham, North Carolina (K.M.G.).
Background: Tissue-based genomic classifiers (GCs) have been developed to improve prostate cancer (PCa) risk assessment and treatment recommendations.
Purpose: To summarize the impact of the Decipher, Oncotype DX Genomic Prostate Score (GPS), and Prolaris GCs on risk stratification and patient-clinician decisions on treatment choice among patients with localized PCa considering first-line treatment.
Data Sources: MEDLINE, EMBASE, and Web of Science published from January 2010 to August 2024.
Dentomaxillofac Radiol
January 2025
Division of Oral Radiology, Faculdade São Leopoldo Mandic.
Objectives: The aim of this technical report was to assess whether the "Radiological Report" tool within the Artificial Intelligence (AI) software Diagnocat can achieve a satisfactory level of performance comparable to that of experienced dentomaxillofacial radiologists in interpreting cone-beam CT scans.
Methods: Ten cone-beam CT scans were carefully selected and analyzed using the AI tool, and they were also evaluated by two dentomaxillofacial radiologists. Observations related to tooth numeration, alterations in dental crowns, roots, and periodontal tissues were documented and subsequently compared to the AI findings.
Neoplasma
December 2024
Department of Pathology and Forensic Medicine, College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
MTHFD2 is highly overexpressed in breast cancer tissues, indicating that it might be used as a target in breast cancer treatment. This study aims to determine the role of MTHFD2 in breast cancer cell proliferation and the molecular pathways involved. In order to investigate MTHFD2 gene expression and its downstream pathways in breast cancer, we started our inquiry with a bioinformatics analysis.
View Article and Find Full Text PDFJ Pediatr Endocrinol Metab
January 2025
Pediatrics, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Objectives: The prevalence and predisposing factors to metabolic dysfunction-associated fatty liver disease (MAFLD) in children with type 1 Diabetes (T1D) living in developing countries are unknown.
Methods: A cross-sectional study was conducted in children with T1D. The presence of liver fat and tissue stiffness were assessed by ultrasonography and shear-wave elastography (SWE), respectively.
Cent Eur J Public Health
December 2024
Department of Public Health and Hygiene, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Kosice, Slovak Republic.
Objectives: Patients suffering from rheumatoid arthritis (RA) are repeatedly affected by oral diseases or problems, including dental caries and periodontal diseases (PDs). Periodontitis and rheumatoid arthritis are chronic inflammatory destructive diseases that share many similarities. The objective of this study was to assess oral health status including examination of hard dental tissues and periodontium in patients with rheumatoid arthritis and compare the results with healthy controls.
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