Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/BF00371742 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
National Council of Scientific and Technical Research (CONICET/UNLP), La Plata, Argentina.
Background: Sporadic Alzheimer's disease (sAD) is the most common form of dementia, characterized by a progressive decline in cognitive function and, cortical and hippocampal atrophy. Our objective is to develop neuroprotective therapies that promote the homeostatic and modulatory properties of astrocytes, and enhance their protective functions. Glial-derived neurotrophic factor (GDNF) has emerged as a promising factor for its ability to promote neuronal survival and function.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Institute for Regenerative Medicine, Department of Cell Biology and Genetics, School of Medicine, Texas A&M University Health Science Center, College Station, Texas, USA., College Station, TX, USA.
Background: Current treatments for Alzheimer's disease (AD) lack disease-modifying interventions. Hence, novel therapies capable of restraining AD progression and maintaining better brain function for extended periods after the initial diagnosis have great significance. Extracellular vesicles (EVs) from human induced pluripotent stem cell (hiPSC)-derived neural stem cells (NSCs) are attractive in this context due to their robust antiinflammatory properties.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
The Ohio State University, Columbus, OH, USA.
Background: Microglia, the innate immune cells of the brain, are a principal player in Alzheimer's Disease (AD) pathogenesis. Their surveillance of the brain leads to interaction with the protein aggregates that drive AD pathogenesis, most notably Amyloid Beta (Aβ). Aβ can elicit attempts from microglia to clear and degrade it using phagocytic machinery, spurring damaging neuroinflammation in the process.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Emory University School of Medicine, Atlanta, GA, USA.
Background: Changes in neuroinflammatory tone have been shown to modulate neuroimmune responses to Alzheimer's disease (AD) pathology and shape disease outcomes, however, extrinsic factors that modify neuroimmune activation remain poorly understood. The gut microbiome is one such factor, with the ability to shape peripheral and central immune activation, as well as AD pathologies. AD patients display unique changes in microbiome composition, however, the link between specific AD-associated gut bacteria, neuroinflammatory tone, and AD outcomes remains to be elucidated.
View Article and Find Full Text PDFBrain modulatory effects of rehabilitation interventions in fibromyalgia: a systematic review of magnetic resonance imaging studies.
Neurol Sci
January 2025
International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan.
Article Synopsis
- Fibromyalgia is a widespread disability that may improve through rehabilitation interventions, but the exact impact on the brain is not fully understood.
- A systematic review was conducted, analyzing 17 studies involving 416 participants to explore how different rehabilitation methods affect brain functions in fibromyalgia patients.
- The findings indicate that rehabilitation can alter brain functions, which correlates with symptom relief, suggesting that brain modulation plays a key role in improving quality of life for those with fibromyalgia and could help predict treatment outcomes.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!