It is known that a prevalence of multiple sclerosis in women is greater than in men (gender ration 2:1). The aim of the study was the analysis of sex differences in the course of disease. On the basis of clinical and paraclinical data, including data concerning mental state of patients emotional disturbances, intellectual functioning the authors determined that the development of multiple sclerosis in men is atypical as compare as women. In men the disease begins earlier and its course is more malignant, without remissions and efficacy of hormonotherapy. The data were interpreted as indicating the importance of the gender factor in the pathogenesis of disease.
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