AI Article Synopsis
- - The study measured the levels of specific polychlorinated biphenyl (PCB) compounds in the blood of rhesus monkeys and their infants before, during, and after pregnancy to assess the effects of Aroclor 1254 on infant development.
- - A notable decrease in higher chlorinated biphenyls was found in the blood of both treated and untreated monkeys during gestation, while lower chlorinated biphenyls increased slightly in milk with higher dosages.
- - Infant blood PCB levels rose during breastfeeding but sharply dropped after weaning, with lower chlorinated biphenyls nearly vanishing by 16 weeks of nursing, indicating a correlation between the PCB levels in mothers and their infants.
Article Abstract
Specific polychlorinated biphenyl (PCB) congeners were measured before, during, and after gestation in the blood of rhesus monkeys, as well as in their milk and in the blood of their infants during lactation, as part of a long-term feeding study to evaluate the toxicology of Aroclor 1254 on pre- and postnatal development of infant monkeys. During gestation a considerable shift from the higher to lower chlorinated biphenyls in the blood was observed in both dosed and nondosed animals. The contribution of penta- and hexachlorobiphenyls in the milk slightly increased with higher dosage. In addition, the percentages of 2,2'3,4,5'-,2,2',4,5,5'-, and 2,3,3',4',6-pentachlorobiphenyls were remarkably lower in the milk of dosed dams than in the originally ingested Aroclor 1254. PCB congener levels in infant blood increased during the lactation period but immediately decreased upon weaning. The lower chlorinated biphenyls virtually disappeared from infant blood after 16 weeks of nursing. Some correlations were observed between PCB congener levels in mother and infant and the congener ratios calculated.
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| http://dx.doi.org/10.1093/jat/19.4.209 | DOI Listing |
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