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Antigenicity evaluation of the synthetic trisaccharides related to Plesiomonas shigelloides serotype O51 O-antigen containing an acetamidino group.
Carbohydr Res
January 2025
School of Biotechnology and Key Laboratory of Carbohydrate Chemistry and Biotechnology of Ministry of Education, Jiangnan University, Lihu Ave. 1800, Wuxi, 214122, China; School of Life Sciences and Health Engineering, Jiangnan University, Lihu Ave. 1800, Wuxi, 214122, China; Innovation Center for Vaccine Engineering, Jiangnan University, Lihu Ave. 1800, Wuxi, 214122, China. Electronic address:
Bacterial surface polysaccharides are widely decorated with diverse rare functional groups. An understanding of the role of these functional groups in immunological activity of the glycans is required for the development of carbohydrate-based treatment against bacterial infectious diseases. Here, the antigenicity evaluation of synthetic trisaccharide 1 related to Plesiomonas shigelloides serotype O51 lipopolysaccharide (LPS) O-antigen and its acetamido derivative 2 was achieved to elucidate the immunological importance of O-antigen structure.
View Article and Find Full Text PDFOlanzapine exposure disordered lipid metabolism, gut microbiota and behavior in zebrafish (Danio rerio).
Comp Biochem Physiol C Toxicol Pharmacol
January 2025
College of Fisheries, Henan Normal University, Xinxiang 453007, PR China; Engineering Technology Research Center of Henan Province for Aquatic Animal Cultivation, Henan Normal University, Xinxiang 453007, PR China. Electronic address:
Olanzapine (OLZ) is widely used in the treatment of schizophrenia, and its metabolic side effects have garnered significant attention in recent years. Despite this, the specific side effects of OLZ and the underlying mechanisms remain inadequately understood. To address this gap, zebrafish (Danio rerio) were exposed to OLZ at concentrations of 35.
View Article and Find Full Text PDFExploring the Adaptation Process of to High Temperatures Based on Changes in Intestinal Microbiota.
Biology (Basel)
December 2024
Key Open Laboratory of Cold Water Fish Germplasm Resources and Breeding of Heilongjiang Province, Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Harbin 150076, China.
Global warming has led to rising water temperatures, posing a significant threat to fish survival. Understanding the mechanisms by which fish respond to and adapt to temperature variations is thus of considerable importance. This study employed high-throughput 16S rRNA gene sequencing and bioinformatics to investigate changes in the intestinal microbiota of the kaluga sturgeon () under four temperature conditions (19 °C, 25 °C, 28 °C, and 31 °C) and its relationship with adaptation to high-temperature stress.
View Article and Find Full Text PDFEffects of prolonged oxytetracycline supplementation on freshwater stinging catfish (): a multi-biomarker approach.
Front Immunol
January 2025
Indian Council of Agriculture Research (ICAR)-Central Institute of Freshwater Aquaculture (CIFA), Fish Health Management Division, Bhubaneswar, Odisha, India.
Background: Aquaculture systems that sporadically depend on antibiotics can contribute to the development of adverse effects on the fish, microbial flora and the environment. This study sought to investigate the impacts of extended oxytetracycline supplementation on the freshwater stinging catfish through a multi-biomarker approach.
Methods: A total of 300 (20 ± 0.
Unexpected mass mortality of black bullhead Ameiurus melas (Rafinesque, 1820) fingerlings occurred 1 week after their arrival at our animal facility. The specimens of the invasive fish species originated from Lake Balaton, the largest natural freshwater lake in Hungary. The mortality reached 100% within 3 days.
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