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Skin and Soft Tissue Infection Complicated by Sepsis in an Immunocompromised Patient: A Rare Case Report.
Clin Case Rep
January 2025
Division of Infectious Diseases, Department of Medicine University of Miami Miller School of Medicine Miami Florida USA.
Physicians should consider non-O1, non-O139 (NOVC) in the differential diagnosis of cellulitis complicated by sepsis, especially in immunocompromised patients when potential exposure exists. Due to the pathogen's potential for severe infections and rising incidence from environmental changes, we emphasize the need for increased awareness and appropriate treatment guidelines.
View Article and Find Full Text PDFProtection by natural cholera against later episodes of cholera over 10 years of follow-up in Matlab, Bangladesh: a retrospective cohort study.
Lancet Microbe
January 2025
International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; International Vaccine Institute, Seoul, South Korea; UCLA Fielding School of Public Health, Los Angeles, CA, USA; Vaccine Innovation Center, Korea University School of Medicine, Seoul, South Korea. Electronic address:
Background: Patients with cholera have been shown to be protected against subsequent cholera for 3 years after their initial episode. We aimed to assess protection at 10 years of follow-up.
Methods: In this retrospective cohort study, cohorts of patients treated for cholera (index patients) and contemporaneously selected age-matched individuals without cholera (controls), randomly selected from the population of Matlab, Bangladesh, were assembled between 1990 and 2009 and followed for up to 10 years.
Effectiveness of a single dose of oral cholera vaccine: findings from epidemiological and genomic surveillance of in the Democratic Republic of the Congo (PICHA7 Program).
medRxiv
December 2024
Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
This study investigated whole-cell oral cholera vaccine (kOCV) single-dose effectiveness and transmission dynamics of through 4 years of epidemiological and genomic surveillance in Democratic Republic of the Congo (DRC). Whole genome sequencing was performed on clinical and water strains from 200 patient households and found annual bimodal peaks of clade AFR10e. 1154 diarrhea patients were enrolled with 342 culture confirmed cholera patients.
View Article and Find Full Text PDFEpidemiology of Infections in the Households of Cholera Patients in the Democratic Republic of the Congo: PICHA7 Prospective Cohort Study.
medRxiv
December 2024
Center for Tropical Diseases & Global Health, Université Catholique de Bukavu, Bukavu B.P 265, Democratic Republic of the Congo.
Background: The aim of this prospective cohort study is to build evidence on transmission dynamics and risk factors for infections in cholera patient households.
Methods: Household contacts of cholera patients were observed for 1-month after the index cholera patient was admitted to a health facility for stool, serum, and water collection in urban Bukavu in South Kivu, Democratic Republic of the Congo. A infection was defined as a bacterial culture positive result during the 1-month surveillance period and/or a four-fold rise in a O1 serological antibody from baseline to the 1-month follow-up.
Biomarkers reflecting disturbed gut barrier under treatment with TNF inhibitors in radiographic axial spondyloarthritis.
RMD Open
December 2024
Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Objectives: The objective of this study is to investigate lipopolysaccharid-binding protein (LBP), zonulin and calprotectin as markers of bacterial translocation, disturbed gut barrier and intestinal inflammation in patients with radiographic axial spondyloarthritis (r-axSpA) during tumour necrosis factor inhibitor (TNFi) therapy and to analyze the association between disease activity, response to treatment and biomarker levels.
Methods: Patients with active r-axSpA of the German Spondyloarthritis Inception Cohort starting TNFi were compared with controls with chronic back pain. Serum levels of LBP, zonulin and calprotectin were measured at baseline and after 1 year of TNFi therapy.
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