Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/978-1-4615-1941-6_77 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Integrating clinical and genomic landscape analysis of perineural invasion identify ACTA1 as an oncogene for oral squamous cell carcinoma.
Front Cell Dev Biol
October 2024
Central Laboratory, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Article Synopsis
- Perineural invasion (PNI) in oral squamous cell carcinoma (OSCC) is linked to advanced tumors and poorer patient outcomes, but the molecular mechanisms and clinical implications are still being studied.
- A study analyzed 279 OSCC samples, finding that PNI is associated with changes in immune cell composition, specifically lower T follicular helper cells and higher M2 macrophages, indicating a potential environment for immune evasion.
- The identified protein Actin α1 (ACTA1) was significantly upregulated in PNI cases and may indicate a sensitivity to immunotherapy, suggesting that patients with high ACTA1 could benefit from treatments targeting cytotoxic T cells.
INTASYL self-delivering RNAi decreases TIGIT expression, enhancing NK cell cytotoxicity: a potential application to increase the efficacy of NK adoptive cell therapy against cancer.
Cancer Immunol Immunother
October 2024
Immunoanalytics-Tissue Control of Immunocytes, Helmholtz Zentrum Munich, Feodor-Lynen-Str. 21, 81377, Munich, Germany.
Natural killer (NK) cells are frontline defenders against cancer and are capable of recognizing and eliminating tumor cells without prior sensitization or antigen presentation. Due to their unique HLA mismatch tolerance, they are ideal for adoptive cell therapy (ACT) because of their ability to minimize graft-versus-host-disease risk. The therapeutic efficacy of NK cells is limited in part by inhibitory immune checkpoint receptors, which are upregulated upon interaction with cancer cells and the tumor microenvironment.
View Article and Find Full Text PDFT cell-mediated tumor killing based signature to predict the prognosis and immunotherapy for glioblastoma.
Heliyon
May 2024
Department of Pathology, The Yiluo Hospital of Luoyang, The Teaching Hospital of Henan University of Science and Technology, Luoyang, China.
Despite the significant advancements in cancer treatment brought by immune checkpoint inhibitors (ICIs), their effectiveness in treating glioblastoma (GBM) remains highly dissatisfactory. Immunotherapy relies on the fundamental concept of T cell-mediated tumor killing (TTK). Nevertheless, additional investigation is required to explore its potential in prognostic prediction and regulation of tumor microenvironment (TME) in GBM.
View Article and Find Full Text PDFExploring the importance of m5c in the diagnosis and subtype classification of COPD using the GEO database.
Gene
February 2024
Glaucoma, Eye Hospital China academy of Chinese Medical Sciences, Beijing 100040, China. Electronic address:
Background: 5-Methylcytosine (m5C) is an mRNA modifier that is associated with the occurrence and development of viral infection, pulmonary fibrosis, lung cancer, and other diseases. However, the role of m5C regulators in chronic obstructive pulmonary disease (COPD) remains unknown.
Methods: In this study, by analysing the GSE42057 dataset, the differential expression of m5c regulators in the COPD group and control group was obtained, and a correlation analysis was conducted.
Staphylococcal Enterotoxin C2 Mutant-Induced Antitumor Immune Response Is Controlled by CDC42/MLC2-Mediated Tumor Cell Stiffness.
Int J Mol Sci
July 2023
Institute of Applied Ecology, Chinese Academy of Sciences, No. 72 Wenhua Road, Shenyang 110016, China.
As a biological macromolecule, the superantigen staphylococcal enterotoxin C2 (SEC2) is one of the most potent known T-cell activators, and it induces massive cytotoxic granule production. With this property, SEC2 and its mutants are widely regarded as immunomodulating agents for cancer therapy. In a previous study, we constructed an MHC-II-independent mutant of SEC2, named ST-4, which exhibits enhanced immunocyte stimulation and antitumor activity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!