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The Novel HLA-DPB1*1617:01 Allele Characterised by Two Different Sequencing-Based Typing Techniques.
HLA
January 2025
HLA and Histocompatibility Laboratory, CHRU de Nancy, Vandœuvre-lès-Nancy, France.
The novel allele HLA-DPB1*1617:01 differs from HLA-DPB1*05:01:01:01 by one non-synonymous nucleotide substitution in exon 2.
View Article and Find Full Text PDFCharacterisation of the Novel HLA-DPB1*1641:01 Allele by Next-Generation Sequencing.
HLA
December 2024
Department of Medical Genetics, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan, China.
Article Synopsis
- - HLA-DPB1*1641:01 and DPB1*02:02:01:01 are two variants of the HLA-DPB1 gene.
- - They differ by a single nucleotide change, where a guanine (G) at position 668 is substituted with an adenine (A).
- - This nucleotide substitution occurs specifically in exon 4 of the gene, which can affect the function or expression of the protein it encodes.
From clones to immunopeptidomes: New developments in the characterization of permissive HLA-DP mismatches in hematopoietic cell transplantation.
Best Pract Res Clin Haematol
September 2024
Institute for Experimental Cellular Therapy, University Hospital Essen, Germany. Electronic address:
Mismatching at the HLA-DPB1 locus occurs frequently in hematopoietic cell transplantation with unrelated donors. Despite this, HLA-DPB1 allelic mismatches have traditionally not been considered in patient-donor matching. A T-cell epitope (TCE) model for the functional assessment of permissive mismatches at this locus has nevertheless been adopted in clinical practice.
View Article and Find Full Text PDFHLA diversity unveils susceptibility and organ-specific occurrence of second primary cancers: a prospective cohort study.
BMC Med
October 2024
Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan 2nd Road, Guangzhou, 510080, Guangdong, China.
Article Synopsis
- * In a study involving 47,550 cancer patients, researchers found specific protective and hazardous HLA alleles linked to SPC, with certain alleles reducing risk while others increased it, particularly in relation to organ-specific occurrences.
- * The findings indicate that HLA alleles could act as biomarkers for SPC susceptibility, and that diet may influence risk, highlighting the need for personalized dietary recommendations based on HLA status.
Cluster of Differentiation Markers and Human Leukocyte Antigen Expression in Chronic Lymphocytic Leukemia Patients: Correlations and Clinical Relevance.
Curr Issues Mol Biol
September 2024
Immunology and Transplant Immunology, Carol Davila University of Medicine and Pharmacy, 258 Fundeni Avenue, 022328 Bucharest, Romania.
Chronic lymphocytic leukemia (CLL) is a distinct category of lymphoproliferative disorder characterized by the clonal expansion of mature B cells, followed by their accumulation in primary and secondary lymphoid organs. Cluster of differentiation (CD) markers such as CD79b, CD45, CD23, CD22 and CD81 serve as reliable prognostic indicators in CLL as well as the human leukocyte antigen (HLA) with its well-documented associations with various cancers. This study aims to investigate, for the first time, potential connections between HLA typing and CD marker expression in CLL.
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