A series of 1-phenyl-3-(aminomethyl)pyrroles were prepared in two steps from aniline and their affinities for D2, D3, and D4 dopamine receptor subtypes determined. A 15-fold selectivity for cloned human D4 receptors over cloned African Green monkey D2 receptors was observed with 1-(2-pyridyl)-4-[[3-(1-phenylpyrrolyl)]methyl]piperazine.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/jm00025a013 | DOI Listing |
Publication Analysis
Top Keywords
dopamine receptor
8
1-phenyl-3-aminomethylpyrroles potential
4
potential antipsychotic
4
antipsychotic agents
4
agents synthesis
4
synthesis dopamine
4
receptor binding
4
binding series
4
series 1-phenyl-3-aminomethylpyrroles
4
1-phenyl-3-aminomethylpyrroles prepared
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!