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Therapeutic Potential of Combined 5% Lifitegrast and Tocopherol Eye Drops in Managing Inflammation and Oxidative Stress in Murine Dry Eye.
Pharmaceuticals (Basel)
January 2025
Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju 61469, Republic of Korea.
: This study aimed to evaluate the therapeutic effects of combined 5% lifitegrast (LF) and tocopherol (TCP) eye drops in a murine experimental dry eye (EDE) model. Female C57BL/6 were divided into seven groups: untreated controls, EDE control, EDE + 0.05% cyclosporin A (CsA), EDE + tocopherol (TCP), EDE + 5% LF, EDE + 5% LF + TCP (once daily), and EDE + 5% LF + TCP (twice daily).
View Article and Find Full Text PDFA multicentre, retrospective study of epidemiology and outcome of aplastic anaemia among adult population in Sabah and Sarawak from year 2006 to 2017.
Med J Malaysia
November 2024
Queen Elizabeth Hospital, Department of Medicine, Haematology Unit, Sabah, Ministry of Health, Malaysia.
Introduction: Aplastic anaemia (AA) is a rare disorder of bone marrow failure, characterized by bone marrow hypocellularity with pancytopenia. The annual incidence rates of AA in Asia are observed to be two to three times higher than Europe and North America. Since the introduction of immunosuppressive therapy (IST) and of allogenic stem cell transplant (SCT), the outcome of severe AA has significantly improved.
View Article and Find Full Text PDFMaintenance immunosuppressive therapy in liver transplantation: results from CESIT study, an Italian retrospective cohort study.
BMJ Open
November 2024
Department of Epidemiology, Lazio Regional Health Service, Roma, Lazio, Italy
Objectives: To investigate the use of maintenance immunosuppressive treatments following liver transplantation and to compare their risk-benefit profiles in clinical practice.
Design: Retrospective multicentrer cohort study.
Setting: Four Italian regions (Lombardy, Veneto, Lazio, Sardinia).
Cyclosporine plus avatrombopag versus cyclosporine monotherapy for first-line treatment of elderly patients with transfusion-dependent non-severe aplastic anemia: a single center retrospective study.
Ann Med
December 2024
Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China.
Article Synopsis
- - The study focuses on elderly patients (60+) with transfusion-dependent non-severe aplastic anemia (TD-NSAA), who have limited treatment options due to compatibility and safety issues.
- - Researchers compared two treatment regimens: avatrombopag (AVA) plus cyclosporine (CsA) and CsA alone, finding a notably higher overall response rate and complete response rate in those receiving AVA + CsA.
- - The combination treatment also led to quicker responses and greater independence from platelet transfusions, suggesting it is a promising option for elderly patients with TD-NSAA.
2023 guidelines on the management of psoriasis by the Dermatological Society of Singapore.
Ann Acad Med Singap
September 2024
Dr SN Wong Skin, Hair, Nails & Laser Specialist Clinic, Singapore.
Article Synopsis
- Psoriasis is a chronic inflammatory skin disease that requires varied management approaches, which the study aimed to standardize through new guidelines tailored for dermatology practice in Singapore.
- A specialized workgroup conducted a comprehensive literature review on psoriasis treatments from 2013 to 2023, refining clinical questions to create practical guidelines covering assessment and management strategies for different severity levels of psoriasis.
- The resulting guidelines suggest various therapies, including both systemic and topical treatments, while addressing specific concerns for special populations and providing recommendations for managing related conditions like psoriatic arthritis.
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