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A Comparative Effect of 12-Week Dietary Intervention of Policosanol (Raydel) and Red Yeast Rice (RYR, Kobayashi) in Managing Dyslipidemia and Organ Damage in Hyperlipidemic Zebrafish.
Pharmaceuticals (Basel)
February 2025
Raydel Research Institute, Medical Innovation Complex, Daegu 41061, Republic of Korea.
Background: A comparative 12-week dietary intervention of red yeast rice (RYR, , Kobayashi, Japan) and Cuban policosanol (PCO, Raydel, Thornleigh, Australia) was assessed for dyslipidemia, antioxidant status, and vital organ functionality in hyperlipidemic zebrafish.
Methods: Hyperlipidemic zebrafish were supplemented with a high-cholesterol diet (HC, final 4%, /) infused with either a powdered RYR tablet (final 1.0%, /), a PCO tablet (final 1.
Case report: Multi-organ injuries induced by tislelizumab.
Front Immunol
February 2025
Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China.
The use of immune checkpoint inhibitors (ICIs) often develops immune-related adverse events (irAEs). However, irAEs-induced multi-organ injuries remain a rare event. We herein report a case of multi-organ injuries induced by tislelizumab in a lung squamous cell carcinoma (LUSC) patient.
View Article and Find Full Text PDFExploring the anti-diabetic properties of camel milk: effects on blood glucose, antioxidant defense, and organ histo-morphological features in rabbits.
J Mol Histol
February 2025
Faculty of Veterinary and Animal Sciences, Lasbela University of Agriculture Water and Marine Sciences, Uthal, 90150, Pakistan.
Camel milk (CM) has acquired substantial consideration in contemporary years owing to its potential prospective pharmaceutical benefits besides nutritional properties. As, CM retain inimitable composition and attain sophisticated concentration of bioactive compounds, thus helps in regulation of blood glucose level, and improves insulin sensitivity. Contemporary study intends to explore anti-diabetic inflictions of CM, besides body weight, blood profile, antioxidant defense and organ integrity in diabetic rabbits.
View Article and Find Full Text PDFCan Metabolic Biomarkers of Oxygen- Dependent Processes Determine Health Status of Pigeon Columba Livia F. Urbana?
Cell Physiol Biochem
February 2025
Pomeranian University in Słupsk, Institute of Biology, Słupsk, Poland.
Background/aims: Anthropogenic impact is irreversibly changing natural habitats of birds. Changes caused by the bioaccumulation of trace metals can lead to the development of oxidative stress and affect oxygen-dependent metabolic pathways in bird tissues, which can be used as effective bioindicators in these conditions. The objectives of our study were (a) to investigate the tissue-specific activity of key enzymes involved in metabolic changes and energy production, including Krebs cycle enzymes, as well as variations in metabolites associated with oxygen-dependent processes; and (b) to apply multivariate regression analysis, using beta and correlation coefficients, to elucidate the mechanisms of adaptive responses in pigeons to environmental changes in lead-contaminated areas.
View Article and Find Full Text PDFPolysaccharides extracted from Polygonatum sibiricum alleviate intestine-liver-kidney axis injury induced by citrinin and alcohol co-exposure in mice.
Food Chem Toxicol
March 2025
School of Food Science and Technology, International Joint Laboratory on Food Safety, Synergetic Innovation Center of Food Safety and Quality Control, Jiangnan University, Wuxi, Jiangsu, 214122, PR China; Institute of Future Food Technology, JITRI, Yixing, Jiangsu, 214200, PR China. Electronic address:
Citrinin (Cit) is a metabolite of Monascus Aspergillus that is known to be nephrotoxic and affects the safety of Monascus products. Here, we investigated the effects of an intervention with bioactive Polygonatum sibiricum polysaccharides (PSPS) on Cit-induced toxic damage in populations with dietary patterns characterized by alcohol consumption. Our results showed that the PSPS intervention significantly increased the levels of intestinal Cit and its metabolite M1.
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