Objective: To ascertain the prevalence of the use of oestrogen replacement therapy in the South Australian community. DESIGN AND SETTING. Data was collected as part of the South Australian Health Omnibus Survey which involved a clustered, self-weighting, multi-stage, systematic representative area sample of 4608 households in metropolitan and country South Australia. One-thousand and forty-seven women over the age of 40 were personally interviewed by trained data collectors.
Outcome Measures: Demographic characteristics, prevalence of current or past oestrogen use, type of oestrogen used, period of use and reasons for using, stopping or never using therapy.
Results: Current use of oestrogen replacement therapy is 13.6% and ever use was 24.3%. The highest prevalence of use was in the age group 45-54 years. Use of oestrogen replacement therapy associated with women born in the UK or Ireland, middle income earners, intermediate education, recent visits to a general practitioner, a current relationship, previous hysterectomy and smoking. The commonest period of use for current users was 1-5 years and the longest 30 years. In contrast many past users had stopped within 6 months, usually because of side effects. The commonest reasons for oestrogen use were to alleviate symptoms, 'following hysterectomy' and to prevent osteoporosis. Only 4.3% took oestrogen to reduce the risk of heart attack or stroke. Reasons for not taking therapy were often due to the woman being premenopausal, having no symptoms or ignorance of the therapy.
Conclusion: Nearly one quarter of women over the age of 40 have used oestrogen replacement therapy. In general there is a perception only of the short term benefits amongst the current users and there is misinformation amongst the non-users. Therapy is often stopped after a very short time because of minor side effects.
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http://dx.doi.org/10.1016/0378-5122(93)90063-n | DOI Listing |
J Endocrinol Invest
January 2025
Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, 40138, Italy.
Purpose: Galactosemia is a rare inborn error of galactose metabolism. There are several forms, the most severe being classic galactosemia (CG), which begins in the first few days of life. Nowadays, it is possible to screen CG at birth, averting acute decompensation or death through diet.
View Article and Find Full Text PDFAsian J Androl
January 2025
Global Andrology Forum, 130 West Juniper Lane, Moreland Hills, OH 44022, USA.
Azoospermia, defined as the absence of sperm in the ejaculate, is a well-documented consequence of exogenous testosterone (ET) and anabolic-androgenic steroid (AAS) use. These agents suppress the hypothalamic-pituitary-gonadal (HPG) axis, leading to reduced intratesticular testosterone levels and impaired spermatogenesis. This review examines the pathophysiological mechanisms underlying azoospermia and outlines therapeutic strategies for recovery.
View Article and Find Full Text PDFBiol Sex Differ
January 2025
Department of Nuclear Medicine, University Hospital Zurich, Zurich, CH-8091, Switzerland.
Background: Presentations and outcomes of acute myocardial infarction (MI) differ between women and men, with the worst outcomes being reported in younger women. Mental stress induced ischemia and sympathetic activation have been suggested to play a prominent role in the pathogenesis of MI in younger women, however, the impact of sex hormones on these parameters remains unknown.
Methods: The effect of sex hormones and age on myocardial infarct size and myocardial sympathetic activity (MSA) was assessed in male and female, as well as young (4-6 months) and aged (20-22 months) FVB/N mice (n = 106, 60 gonadectomized and 46 sham-operated animals) who underwent in vivo [C]meta-hydroxyephedrine ([C]mHED) positron emission tomography (PET) and cardiac magnetic resonance (CMR) imaging 24 h after a 30 min myocardial ischemic injury.
BMC Womens Health
January 2025
Women's Hospital, School of Medicine, Zhejiang University, 1st Xueshi Rd, Hangzhou, 310006, Zhejiang Province, People's Republic of China.
Background: The etiology of depression involves many biological and environmental factors, among which the inflammatory process is an important contributor. However, the role of pro-inflammatory cytokines in postmenopausal depression is unclear. Therefore, we aimed to explore the association between the serum concentrations of four pro-inflammatory cytokines (IL-1β, IL-6, IL-18, and TNF-α) and depressive symptoms in postmenopausal women who had been receiving menopause hormone therapy (MHT) for at least 6 months and postmenopausal women who had not received MHT.
View Article and Find Full Text PDFEur J Endocrinol
January 2025
Department of Internal Medicine IV, LMU University Hospital, LMU Munich, 80336 Munich, Germany.
Objective: The effects of sex hormones remain largely unexplored in pheochromocytomas and paragangliomas (PPGLs) and gastroenteropancreatic neuroendocrine tumors (GEP-NETs).
Methods: We evaluated the effects of estradiol, progesterone, Dehydroepiandrosterone sulfate (DHEAS), and testosterone on human patient-derived PPGL/GEP-NET primary culture cell viability (n = 38/n = 12), performed next-generation sequencing and immunohistochemical hormone receptor analysis in patient-derived PPGL tumor tissues (n = 36).
Results: In PPGLs, estradiol and progesterone (1 µm) demonstrated overall significant antitumor effects with the strongest efficacy in PPGLs with NF1 (cluster 2) pathogenic variants.
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