Optic nerve sheath fenestration is an increasingly useful surgical technique for relief of visual loss due to a number of optic disc pathologic conditions. To date, surgeons have employed either a medial approach with disinsertion of the medial rectus muscle or a lateral approach with removal of the lateral orbital rim to gain access to the retrobulbar optic nerve. We report herein a technique for approaching the optic nerve through a lateral canthotomy incision that does not require removal of bone or disinsertion of an extraocular muscle. It has been used to provide ready surgical exposure of the optic nerve in 17 eyes of 14 patients. This technique combines the advantages of lateral exposure of the optic nerve with an ease of operation similar to that of the medial approach.
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http://dx.doi.org/10.1001/archopht.1993.01090060160042 | DOI Listing |
Morphologie
January 2025
Department of Anatomy, Faculty of Medicine-Pharmacy, University of Rouen-Normandy, Rouen, France.
The optic canal (OC) transmits the optic nerve (ON) and ophthalmic artery (OA) from the skull base to the orbit. Its morphological variability is narrow, and most commonly its dimensions are being studied. We observed an unexpected variant during a routine investigation of our osteological collection.
View Article and Find Full Text PDFASN Neuro
January 2025
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USA.
In light of the increasing importance for measuring myelin ratios - the ratio of axon-to-fiber (axon + myelin) diameters in myelin internodes - to understand normal physiology, disease states, repair mechanisms and myelin plasticity, there is urgent need to minimize processing and statistical artifacts in current methodologies. Many contemporary studies fall prey to a variety of artifacts, reducing study outcome robustness and slowing development of novel therapeutics. Underlying causes stem from a lack of understanding of the myelin ratio, which has persisted more than a century.
View Article and Find Full Text PDFCNS Neurosci Ther
January 2025
Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran.
Background: Multiple sclerosis (MS) is an autoimmune disorder affecting the central nervous system, with varying clinical manifestations such as optic neuritis, sensory disturbances, and brainstem syndromes. Disease progression is monitored through methods like MRI scans, disability scales, and optical coherence tomography (OCT), which can detect retinal thinning, even in the absence of optic neuritis. MS progression involves neurodegeneration, particularly trans-synaptic degeneration, which extends beyond the initial injury site.
View Article and Find Full Text PDFJ Neuroimaging
January 2025
Department of Neurology, Baylor College of Medicine, Houston, Texas, USA.
Intracranial pressure (ICP) monitoring is a cornerstone of neurocritical care in managing severe brain injury. However, current invasive ICP monitoring methods carry significant risks, including infection and intracranial hemorrhage, and are contraindicated in certain clinical situations. Additionally, these methods are not universally available.
View Article and Find Full Text PDFFront Neurol
January 2025
Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun, China.
Retinal ganglion cells (RGCs) generally fail to regenerate axons, resulting in irreversible vision loss after optic nerve injury. While many studies have shown that modulating specific genes can enhance RGCs survival and promote optic nerve regeneration, inducing long-distance axon regeneration through single-gene manipulation remains challenging. Nevertheless, combined multi-gene therapies have proven effective in significantly enhancing axonal regeneration.
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