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Comparison of lowest energy conformations of dimethylcurine and methoxyverapamil: evidence of ternary association of calcium channel, Ca2+, and calcium entry blockers.
J Membr Biol
August 1993
Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada.
Verapamil and dimethylcurine are Ca2+ entry blockers of essentially different chemical structures which presumably bind to the same arylalkylamine receptor of the L-type Ca channel. A systematic conformational analysis of methoxyverapamil (D-600) and dimethylcurine has been carried out using a molecular mechanics method. The lowest minimum-energy conformations of D-600 are predisposed to chelate Ca2+ by four oxygen atoms of the stacked methoxyphenyl moieties.
View Article and Find Full Text PDFChanges in cerebrospinal fluid pressure and spinal cord perfusion pressure prior to cross-clamping of the thoracic aorta in humans.
J Cardiothorac Vasc Anesth
August 1991
Department of Cardiothoracic Anesthesiology, Cleveland Clinic, OH.
Little is known about what influences cerebrospinal fluid pressure (CSFP) during anesthesia prior to aortic cross-clamping (AXC). Therefore, this study measured the effect of anesthetic induction, of various drugs administered during the course of surgery prior to AXC, and of hemodynamic changes on CSFP, and calculated spinal cord perfusion pressure (SCPP = mean arterial pressure [MAP] - CSFP) in 11 patients undergoing surgery on the descending thoracic aorta. A lumbar drainage catheter was placed to facilitate drainage of CSF and to measure CSFP.
View Article and Find Full Text PDFA comparison of parametric with semiparametric analysis of the concentration versus effect relationship of metocurine in dogs and pigs.
J Pharmacokinet Biopharm
June 1989
Department of Anesthesia, Stanford University Medical Center, California.
We investigated the ability of two pharmacokinetic modeling techniques to estimate the equilibration delay (i.e., hysteresis) between plasma drug concentration and observed drug effect.
View Article and Find Full Text PDFEffect of thermal injury on the pharmacokinetics and pharmacodynamics of atracurium in humans.
Anesthesiology
May 1989
Department of Pharmaceutics, University of Washington, Seattle 98195.
Thermal injury causes resistance to many nondepolarizing muscle relaxants including d-tubocurarine, metocurine, pancuronium, and atracurium. To evaluate the role of pharmacokinetics and pharmacodynamics in this phenomenon, the disposition and effect of atracurium (0.5 mg/kg iv) were studied in thermally injured patients (5 males, 16-43 yr) in comparison with that in nonburned control patients (3 males, 1 female, 24-53 yr).
View Article and Find Full Text PDFEffects of anesthetic induction on myocardial function and metabolism: a comparison of fentanyl, sufentanil and alfentanil.
Can J Anaesth
May 1988
Division of Clinical Biochemistry, Toronto General Hospital, University of Toronto, Ontario.
Anaesthetic induction may induce myocardial ischaemia. A prospective randomized trial was instituted to compare the effect on ventricular function and myocardial metabolism of induction with fentanyl (FEN) or its analogues sufentanil (SUF) or alfentanil (ALF) in 96 patients undergoing elective coronary artery bypass grafting (CABG). Haemodynamic, metabolic (coronary sinus oxygen and lactate extraction) and gated ventriculographic measurements were made awake pre-induction (PRE), after induction (IND) and after intubation (INT).
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