Interleukin-1 beta (Il-1 beta) is a cytokine which is considered to play a role in inducing the inflammatory reaction and the bone resorption that takes place in periodontal disease. With the aim of studying the presence and location of Il-1 beta positive cells in this disease, human gingival tissues from 12 patients with periodontitis and from 4 healthy control subjects were examined by immunohistochemical analysis. The cytokine was detected in all the patients having untreated periodontitis, although its content in gingival tissues revealed considerable variations among subjects. Il-1 beta was mainly localized within macrophage-like cells. Il-1 beta positive cells were not present in normal gingival tissue; however in 2 of the subjects considered normal there were few Il-1 beta positive cells in small areas of inflammation present in proximity of the dento-gingival junction.
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