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Braimah-Taiwo et al New Classification System and Treatment Algorithm of Mandibulo-Maxillary Synostosis Related to Noma. Field Experience From Noma Children Hospital Sokoto, Nigeria.
Craniomaxillofac Trauma Reconstr
December 2024
Department of Dental & Maxillofacial Surgery, Federal Medical Centre, Birnin Kebbi, Nigeria.
Study Design: This was a retrospective study at Noma Children Hospital, Sokoto, Nigeria, from January 2018 to December 2021.
Objective: The main objective of this appraisal was to present Braimah-Taiwo et al's new classification system for mandibulo-maxillary synostosis secondary to noma and also to provide a guide to their treatment.
Methods: Noma with mandibulo-maxillary synostosis was the main inclusion criteria.
NK2R control of energy expenditure and feeding to treat metabolic diseases.
Nature
November 2024
Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Article Synopsis
- - The study highlights the potential of activating the neurokinin 2 receptor (NK2R) as a dual approach to combat obesity and type 2 diabetes by suppressing appetite and increasing energy expenditure, representing a significant advancement over current multi-drug strategies.
- - Researchers developed long-acting NK2R agonists that can be administered weekly, which showed promising results in mice, leading to weight loss and improved insulin sensitivity without relying on traditional leptin signaling.
- - In tests with diabetic, obese macaques, NK2R activation resulted in substantial reductions in body weight, blood glucose, and cholesterol levels, suggesting a single-target therapeutic option that enhances energy balance and addresses cardiometabolic issues across different species.
Concomitant Popliteomeniscal Fascicles Tears Are Found in 21% of Professional Soccer Players With Acute Anterior Cruciate Ligament Injuries.
Arthrosc Sports Med Rehabil
October 2024
Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University of Rome, Rome, Italy.
Purpose: To investigate the incidence of popliteomeniscal fascicles (PMF) tears in anterior cruciate ligament (ACL) rupture in professional soccer players, to describe arthroscopic and magnetic resonance imaging (MRI) findings and treatment of these lesions with clinical outcomes, and to evaluate the incidence of subsequent lateral meniscus tears and ACL reinjury.
Methods: ACL reconstructions on soccer players were retrospectively analyzed, and among them, a cohort of patients with PMFs tears was reviewed. The cohort was assessed with MRI examination, arthrometric testing, Lysholm score, and International Knee Documentation Committee score.
The etiology of temporomandibular disorders (TMDs) is remarkably diverse. This case report highlights the use of clear aligners as a probable cofactor of TMD in an adult patient. A 56-year-old woman who presented with a chief concern of crowding was missing teeth in both arches and had generalized tooth wear, an indistinct history of temporomandibular joint musculoskeletal pain, and a self-reported history of clenching.
View Article and Find Full Text PDFSex differences in the orofacial antinociceptive effect of metformin and the role of transient receptor potential channels.
Naunyn Schmiedebergs Arch Pharmacol
October 2024
Experimental Biology Center, University of Fortaleza, Fortaleza, Brazil.
Metformin is classified as a biguanide and is used in the treatment of type 2 diabetes. It is used worldwide and has been investigated in drug repositioning. The present study aims to investigate whether there is sexual dimorphism in the orofacial antinociceptive effect of metformin and the participation of TRP channels.
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