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Thrombus composition and its implication in ischemic stroke assessment and revascularization treatments.
Neurologia (Engl Ed)
December 2024
Servicio de Neurología, Hospital Universitario Navarra, Pamplona, Navarra, Spain; RICORS-ICTUS, ISCIII, Madrid, Spain.
Introduction: Since mechanical thrombectomy has allowed ischaemic stroke thrombus retrieval, the exhaustive study of this material has enabled better understanding of the potential physiopathological processes involved in thrombus formation.
Development: Thrombotic pathways involved in the different vascular beds share common mechanisms, causing difficulties in the identification of specific patterns associated with stroke aetiology. However, other factors such as clot formation time, associated inflammatory status, or activation of additional immune and coagulation pathways (neutrophil extracellular trap [NET] delivery, platelet aggregation, endothelial activation, and von Willebrand Factor release) have been described as determinants in thrombus characteristics.
Cerebrospinal fluid markers of neuroinflammation and coagulation in severe cerebral edema and chronic hydrocephalus after subarachnoid hemorrhage: a prospective study.
J Neuroinflammation
September 2024
Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang, 310009, China.
Article Synopsis
- Early severe cerebral edema and chronic hydrocephalus significantly worsen the prognosis for patients with subarachnoid hemorrhage (SAH), prompting investigators to explore the role of inflammatory cytokines and coagulation factors in these conditions.
- A study involving 72 SAH patients categorized them by severity of cerebral edema and subsequent development of hydrocephalus, measuring levels of various inflammatory and coagulation factors in cerebrospinal fluid (CSF) shortly after SAH.
- Findings revealed that certain coagulation factors and inflammatory cytokines were strongly linked to both severe cerebral edema and chronic hydrocephalus, and a mouse model suggested that treatment with tissue plasminogen activator could help reduce inflammation and related brain swelling.
Characterizing Histopathologic Features in Pregnancies With Chronic Histiocytic Intervillositis Using Computerized Image Analysis.
Arch Pathol Lab Med
April 2024
From Tommy's Maternal and Fetal Health Research Centre, St Mary's Hospital, The University of Manchester, Manchester, United Kingdom (Brady, Riley, Crocker, Heazell).
Context.—: Chronic histiocytic intervillositis (CHI) is a rare condition characterized by maternal immune cell infiltration into the human placenta. CHI is strongly associated with fetal growth restriction, miscarriage, and stillbirth, and knowledge of its etiology, and consequently effective treatment, is limited.
View Article and Find Full Text PDFMicropatterning of acoustic droplet vaporization in acoustically-responsive scaffolds using extrusion-based bioprinting.
Bioprinting
March 2022
Department of Radiology, University of Michigan, Ann Arbor, MI, USA.
Acoustically-responsive scaffolds (ARSs) are composite hydrogels that respond to ultrasound in an on-demand, spatiotemporally-controlled manner due to the presence of a phase-shift emulsion. When exposed to ultrasound, a gas bubble is formed within each emulsion droplet via a mechanism termed acoustic droplet vaporization (ADV). In previous and studies, we demonstrated that ADV can control regenerative processes by releasing growth factors and/or modulating micromechanics in ARSs.
View Article and Find Full Text PDFFibrin to von Willebrand factor ratio in arterial thrombi is associated with plasma levels of inflammatory biomarkers and local abundance of extracellular DNA.
Thromb Res
January 2022
Department of Biochemistry, Semmelweis University, Budapest, Hungary. Electronic address:
Introduction: The composition of thrombi determines their structure, mechanical stability, susceptibility to lysis, and consequently, the clinical outcome in coronary artery disease (CAD), acute ischemic stroke (AIS), and peripheral artery disease (PAD). Fibrin forms the primary matrix of thrombi intertwined with DNA, derived from neutrophil extracellular traps (NETs), and von Willebrand factor (VWF) bridging DNA and platelets. Here we examined the relative content of fibrin, DNA and VWF in thrombi and analyzed their interrelations and quantitative associations with systemic biomarkers of inflammation and clinical characteristics of the patients.
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