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The Role of SIRT1-BDNF Signaling Pathway in Fluoride-Induced Toxicity for Glial BV-2 Cells.
Biol Trace Elem Res
January 2025
Department of Hematology, Affiliated Hospital of Guizhou Medical University, No. 4 Bei Jing Road, Yunyan District, Guiyang, 550004, Guizhou Province, China.
Chronic fluorosis is often accompanied by neurological symptoms, leading to attention, memory and learning ability decline and causing tension, anxiety, depression, and other mental symptoms. In the present study, we analyzed the molecular mechanisms of SIRT1-BDNF regulation of PI3K-AKT, MAPK, and FOXO1A in F-treated BV2 cells. The cytotoxic effect of sodium fluoride (NaF) on BV2 cells was assessed using Cell Counting Kit-8 (CCK-8), crystal violet, and 5-ethynyl-2'-deoxyuridine (EdU) staining.
View Article and Find Full Text PDFHydrochemical fingerprints and health risk assessment of groundwater contamination in the Bohai Sea region, China.
Mar Pollut Bull
January 2025
College of Environmental Science and Engineering, Nankai University, Tianjin 300350, PR China.
Seawater intrusion and human activities have significantly impacted coastal groundwater quality in many regions worldwide. This study systematically assessed groundwater chemistry, its suitability for drinking and irrigation (sample size, n = 3034), and exposure risks (n = 2863) across three key sub-regions of the Bohai Sea area: Bohai Bay, Liaodong Bay, and Laizhou Bay. Significant seasonal variations observed in groundwater chemistry at different depths in Bohai Bay region, with severe contamination from salinity-alkalinity and nitrogen-fluoride.
View Article and Find Full Text PDFA Randomized Clinical Study Investigating the Stain Removal Efficacy of Two Experimental Dentifrices.
J Esthet Restor Dent
January 2025
All Sum Research Center Ltd., Mississauga, Ontario, Canada.
Objective: This study aims to evaluate extrinsic tooth stain removal and whitening efficacy of two experimental dentifrices containing (i) 5% sodium tripolyphosphate (STP)/1% micronized alumina or (ii) 5% STP/1% micronized alumina with abrasive silica (ED2) compared to a regular fluoride dentifrice (RFD) following 8 weeks of use.
Materials And Methods: This was a single-center, randomized, controlled, blind, three-arm, stratified, parallel-group study. Eligible participants underwent clinical assessment of stain on the facial/lingual surfaces of maxillary and mandibular teeth using the modified Lobene stain index (MLSI), and shade of the facial surfaces of the central and lateral maxillary incisors using the VITA Bleachedguide 3D-Master (VITA) shade guide.
Evaluation of Gluma® and MI Varnish™ for In-Office Treatment of Dentinal Hypersensitivity: An Observational Study.
Cureus
December 2024
Department of Periodontology and Implantology, Government Dental College and Hospital, Jamnagar, Jamnagar, IND.
Introduction In their routine practice, dentists frequently encounter dentinal hypersensitivity, which is caused by the pulpal nerves' increased excitability due to fluid movement in the dentinal tubules. It is treated in-office using dentin desensitizers, which reduce hypersensitivity by obstructing the open tubules or desensitizing the free nerve endings present within the tubules. However, no substance or treatment plan has ever been proven to be the gold standard for the efficient treatment of dentinal hypersensitivity.
View Article and Find Full Text PDFFluoride-Induced Autophagy and Apoptosis in the Mouse Ovary: Genomic Insights into IL-17 Signaling and Gut Microbiota Dysbiosis.
J Agric Food Chem
January 2025
Henan Key Laboratory of Environmental and Animal Product Safety, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan,China.
Chronic fluoride (F) exposure is linked to gonadotoxicity in females, yet the underlying molecular mechanisms remain unclear. This study investigated fluoride-induced reprotoxicity using advanced genomic profiling. RNA-seq analysis identified significant activation of autophagy, apoptosis, and IL-17 signaling pathways in fluoride-exposed female mice.
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