Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Ultraviolet B (UV-B) irradiation of C3H/HeN mice induces skin cancer. In this study, the ability of dietary d-alpha-tocopheryl acetate to reduce photocarcinogenesis was tested in this murine model. Skin cancers developed in 67.5% of UV-B-irradiated mice by 31 weeks after the first UV exposure. Supplementation with 100 or 200 IU of d-alpha-tocopheryl acetate per kilogram of diet led to a reduction of the incidence to 46% and 19%, respectively. The latter value was significantly different from that found in mice fed the basal diet (p = 0.039, one-sided P value by log-rank test). Skin levels of alpha-tocopherol varied with the dietary dose of d-alpha-tocopheryl acetate. No toxicity was evident in unirradiated mice fed the vitamin E-supplemented diet, but 40% of the UV-B-irradiated mice fed 200 IU of vitamin E per kilogram of diet died by 31 weeks after the first UV-B treatment. Decreased relative spleen weight was observed in the UV-B-irradiated mice fed the vitamin E-supplemented diet. In summary, oral d-alpha-tocopheryl acetate prevented photocarcinogenesis, but at doses that were toxic to inbred C3H/HeN mice after exposure to 8.6 x 10(5) J/m2 of UV-B irradiation.
Download full-text PDF |
Source |
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http://dx.doi.org/10.1080/01635589309514243 | DOI Listing |
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