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Prostaglandin pathways in equine myometrium regulations: endometrosis progression.
Front Vet Sci
December 2024
Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research Polish Academy of Science, Olsztyn, Poland.
Introduction: Prostaglandins (PG) are important regulators of the myometrial contractility in mammals. Endometrosis, a condition characterized by morphological changes in the equine endometrium, also affects endometrial secretory function. However, it remains unclear whether and how endometrosis affects myometrial function.
View Article and Find Full Text PDFAcid-sensing ion channel-1 contributes to the failure of myelin sheath regeneration following spinal cord injury by transcellular delivery of PGE2.
Cell Mol Biol Lett
December 2024
Department of Orthopedics (Spinal Surgery), The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, People's Republic of China.
Background: Traumatic injuries to spinal cord lead to severe motor, sensory, and autonomic dysfunction. The accumulation of inhibitory compounds plays a pivotal role in the secondary damage to sparing neural tissue and the failure of axonal regeneration and remyelination. Acid-sensing ion channel-1(ASIC1A) is widely activated following neurotrauma, including spinal cord injury (SCI).
View Article and Find Full Text PDFSpatiotemporal characterization of cyclooxygenase pathway enzymes during vertebrate embryonic development.
Dev Biol
February 2025
Department of Anatomy, Physiology, and Cell Biology, University of California, Davis, School of Veterinary Medicine, Davis, CA, USA. Electronic address:
Vertebrate development is regulated by several complex well-characterized morphogen signaling pathways, transcription factors, and structural proteins, but less is known about the enzymatic pathways that regulate early development. We have identified that factors from the inflammation-mediating cyclooxygenase (COX) signaling pathway are expressed at early stages of development in avian embryos. Using Gallus gallus (chicken) as a research model, we characterized the spatiotemporal expression of a subset of genes and proteins in the COX pathway during early neural development stages.
View Article and Find Full Text PDFLuteal fibroblasts produce prostaglandins in response to IL1β in a MAPK-mediated manner.
Mol Cell Endocrinol
January 2025
Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, NE, USA; US Department of Veterans Affairs VA Medical Center, Omaha, NE, USA. Electronic address:
The corpus luteum is a temporary endocrine gland that is crucial for pregnancy, as it produces the progesterone needed to maintain optimal uterine conditions for implantation. In the absence of a conceptus, the corpus luteum becomes non-functional and undergoes rapid tissue remodeling to regress into a fibrotic corpus albicans. Early luteal regression is characterized by increased cytokine release.
View Article and Find Full Text PDFProliferative Diabetic Retinopathy Microenvironment Drives Microglial Polarization and Promotes Angiogenesis and Fibrosis via Cyclooxygenase-2/Prostaglandin E2 Signaling.
Int J Mol Sci
October 2024
Department of Ophthalmology, Juntendo University Graduate school of Medicine, 2-1-1 Bunkyo, Tokyo 113-8421, Japan.
Diabetic retinopathy (DR) is the leading cause of visual impairment, particularly in the proliferative form (proliferative DR [PDR]). The impact of the PDR microenvironment on microglia, which are the resident immune cells in the central nervous system, and the specific pathological changes it may induce remain unclear. This study aimed to investigate the role of microglia in the progression of PDR under hypoxic and inflammatory conditions.
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