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| http://dx.doi.org/10.1136/bmj.306.6886.1199-b | DOI Listing |
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Abdominal aortic aneurysm is a systemic and generalized arteriomegaly in mice and humans.
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Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Although the pathogenesis of abdominal aortic aneurysm (AAA) remains largely unclear, evidence is accumulating to suggest the systemic nature of this disease. Here, we comprehensively assessed the whole aortic tree with its major branches based on computed tomography angiography (CTA) in AAA patients compared to ascending thoracic aortic aneurysm (ATAA) patients and nonaneurysmal controls, as well as in an original mouse model of AAA in Lkb1;Myh11-Cre/ERT2 mice. The morphology and dimensions of the whole aorta (at different levels) and its major branches were compared among 47 AAA patients, 47 ATAA patients, and 46 nonaneurysmal controls based on CTA images.
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Centre de référence des maladies héréditaires du métabolisme, Hôpital d'enfants, Centre Hospitalier universitaire of Nancy and Faculty of Medicine, Midwifery and Health Professions, Université de Lorraine, F- 54000 Nancy, France; Centre Universitaire d'Enseignement par Simulation - CUESim, Virtual Hospital of Lorraine, Faculty of Medicine, Midwifery and Health Professions, Université de Lorraine, Nancy F- 54000, France; Centre de référence des maladies héréditaires du métabolisme, Hôpital d'enfants, rue Morvan, CHRU de Nancy, F- 54000 Nancy, France; Université de Lorraine, Inserm, DCAC, Nancy, France. Electronic address:
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School of Mechanical Engineering, Purdue University, West Lafayette, IN, USA. Electronic address:
Understanding bone strength is important when assessing bone diseases and their treatment. Bending experiments are often used to determine strength. Then, flexural stresses are calculated from elastic bending theory.
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Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati 781039, Assam, India.
Genistein (GEN), a phytoestrogen primarily sourced from soy plants, is recognized for its anticancer properties attributed to its roles as a tyrosine kinase inhibitor, an estrogen receptor agonist, and its influence on various cancer hallmarks by modulating diverse signaling pathways. Recent research has highlighted the considerable potential of GEN in combating drug resistance in cancer cells. This attribute of GEN has been demonstrated by its capacity to modulate tyrosine kinases such as HER2, HER3, and EGFR which are implicated in tumorigenesis, as well as prosurvival signaling pathways including NF-κB and Akt/mTOR.
View Article and Find Full Text PDF[A Case of Bone Metastatic Breast Cancer with Well-Controlled QOL Treated by Mastectomy Followed by S-1 Administration].
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