We performed phototherapeutic keratectomy (PTK) in seven patients (nine eyes) with superficial corneal disease such as band keratopathy (one patient), Reis-Bückler's dystrophy (one patient, two eyes), granular dystrophy (two patients, three eyes), recurrent granular dystrophy (one patient), postinfection scar (one patient), and corneal scarring after pterygium removal (one patient). All patients received PTK after topical anesthesia with Pontocaine 0.5% and underwent epithelial removal with a surgical blade. We used methylcellulose 1.0% as a surface modulator before laser ablation. Focal ablation of the central cornea with an ablation zone of 5 mm was performed routinely in most eyes and a smoothing technique was applied only in two eyes. All patients were followed for more than 9 months. Uncorrected and corrected visual acuity were significantly improved in six patients (8 eyes) and a mild hyperopic shift occurred in all eyes that received PTK centrally. Mild to moderate corneal haze appeared in these corneas during the first few months after surgery. Some patients avoided the need for keratoplasty. No significant complications occurred after PTK except recurrence of granular deposits in one case of granular dystrophy. We think that PTK with the 193-nanometer excimer laser is indicated in the treatment of some superficial corneal disorders.
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Acta Histochem
January 2025
Section of Anatomy and Histology, Imaging Platform, Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, Florence 50134, Italy. Electronic address:
Epidemic keratoconjunctivitis (EKC) is one of the most severe clinical manifestations of human adenovirus ocular surface infection, which may lead to the formation of subepithelial infiltrates (SEIs) in the anterior corneal stroma in 20-50 % of cases. SEIs may be asymptomatic or give rise to corneal aberrations and visual impairment for months or years after acute infection, despite treatments. Here, we describe the ultrastructural and immunophenotypic features of the anterior corneal stroma of a patient who underwent superficial anterior lamellar keratoplasty (SALK) surgery to remove corneal opacities related to clinically significant and steroid-unresponsive, long-lasting SEIs after adenoviral EKC.
View Article and Find Full Text PDFJ Clin Med
January 2025
Department of Clinical Microbiology, General Hospital "G. Gennimatas", 11527 Athens, Greece.
: is an important phytopathogenic fungus affecting over 500 plant species worldwide. However, this fungus rarely causes disease in humans. : We reported the first case of endophthalmitis due to , describing microbiological diagnostic approaches.
View Article and Find Full Text PDFJ Clin Med
January 2025
Surgical Services, Miami Veterans Healthcare System, Miami, FL 33125, USA.
: This study aimed to evaluate the location of retinal fractal dimension (FD) abnormalities in individuals with diabetes mellitus (DM) and hypertension (HTN) without retinopathy. The annular zone of 6 mm × 6 mm OCTA images centered on the fovea was partitioned into thin annuli and analyzed using fractal analysis to measure FDs. The cohort ( = 114) had an average age of 55.
View Article and Find Full Text PDFBiotech Histochem
January 2025
Faculty of Veterinary Medicine, Department of Pathology, Siirt University, Siirt, Turkiye.
Corneal injuries are common in human and veterinary ophthalmology. There are many studies which have investigated the treatment of corneal epithelial defects. This study aimed to investigate the effects of Neutral Protamine Hagedorn (NPH) insulin as an ointment for wound healing in experimental corneal defects.
View Article and Find Full Text PDFCornea
January 2025
Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Purpose: To describe a case series of patients with 12 fungal keratitis treated with caspofungin 0.5% eye drops.
Methods: In this study, 12 patients diagnosed with fungal keratitis were treated with topical compounded caspofungin 0.
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