Content of lipids in blood serum and membranes of liver tissue endoplasmic reticulum, functional activity of microsomes, antitoxic activity of liver tissue as well as collagen production in rat liver tissue were studied in experimental hepatitis after administration of exogenous lipids (equine erythrocyte phospholipids and ganglioside GM3, bovine spinal cord phospholipids). All the preparations studied inhibited the functional activity of the liver cells which was expressed as a decrease of the lipids content in the microsomes, inhibition of glucose-6-phosphate dehydrogenase activity and impairment of the liver tissue antitoxic functions. Distinct inhibition of these reactions caused an increase of the collagen content in the liver tissue.
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