The results suggest the feasibility of metabolic and behavioral interrelationships between ethanol (ET), certain neurotransmitter substances and major metabolites, some neuropeptides and/or psychoactive agents. This was indicated by the in vivo and in vitro effects of such authentic compounds on certain ET-elicited behavioral responses and on hepatic ET and acetaldehyde metabolizing enzymes in rats and mice.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/978-1-4615-2904-0_62 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Intestinal butyric acid-mediated disruption of gut hormone secretion and lipid metabolism in vasopressin receptor-deficient mice.
Mol Metab
January 2025
Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo 153-8902, Japan. Electronic address:
Objectives: Arginine vasopressin (AVP), known as an antidiuretic hormone, is also crucial in metabolic homeostasis. Although AVP receptor-deficient mice exhibit various abnormalities in glucose and lipid metabolism, the mechanism underlying these symptoms remains unclear. This study aimed to explore the involvement of the gut hormones including glucagon-like peptide-1 (GLP-1) and microbiota as essential mediators.
View Article and Find Full Text PDFAlterations in hippocampal somatostatin interneurons, GABAergic metabolism, and ASL perfusion in an aged male mouse model of POCD aggravated by sleep fragmentation.
Physiol Rep
December 2024
Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China.
Sleep fragmentation (SF) is increasingly recognized as a contributing factor to postoperative cognitive dysfunction (POCD). Given the critical roles of somatostatin (SST) interneurons, associated gamma-aminobutyric acid (GABA)ergic neurotransmitters, and hippocampal perfusion in sleep-related cognition, this study examined changes in these mechanisms in preoperative SF affecting POCD induced by anesthesia/surgery in aged male mice. The Morris water maze (MWM), novel object recognition (NOR), and Y maze tests were utilized to evaluate POCD.
View Article and Find Full Text PDFA multi-omics approach identifies the key role of disorders of sphingolipid metabolism in Ang II-induced hypertensive cardiomyopathy myocardial remodeling.
Sci Rep
December 2024
Department of Cardiology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, No.16369 Jingshi Road, Lixia District, Jinan, 250014, Shandong, China.
Hypertension-induced myocardial remodelling encompasses both structural and functional changes in cardiac muscle tissue, such as myocardial hypertrophy, fibrosis, and inflammation. These alterations not only impair the systolic and diastolic functions of the heart but also elevate the risk of cardiovascular events and heart failure. One of the primary contributors to hypertensive cardiomyopathy (HTN-CM) is the over-activation of the renin-angiotensin-aldosterone system (RAAS), which subsequently induces myocardial remodeling.
View Article and Find Full Text PDFMacrophytes mitigate Microcystis aeruginosa-induced fish appetite suppression via intestinal metabolite regulation.
Ecotoxicol Environ Saf
December 2024
Yunnan Collaborative Innovation Center for Plateau Lake Ecology and Environmental Health, College of Agronomy and Life Sciences, Kunming University, Kunming 650214, China; Great Lakes Institute for Environmental Research, University of Windsor, Windsor, ON N9B 3P4, Canada. Electronic address:
Article Synopsis
- Cyanobacterial blooms, specifically Microcystis aeruginosa, and aquatic plants like Ottelia acuminata can significantly impact the health and behavior of freshwater fish, particularly affecting their appetite and metabolism.
- In a study involving stone moroko fish, exposure to M. aeruginosa led to an increase in appetite-inhibiting substances and a decrease in stimulatory ones, which indicates heightened stress levels related to their metabolic functions.
- Interestingly, O. acuminata did not negatively affect the fish alone but appeared to mitigate some harmful effects of M. aeruginosa, suggesting a potential protective role worth further investigation.
Potential biomarkers for lameness and claw lesions in dairy cows: A scoping review.
J Dairy Res
October 2024
Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Malaysia.
Article Synopsis
- Detecting lameness in dairy cows before visible signs appear is a significant challenge, and this review explores various biomarkers that could help in early diagnosis and monitoring recovery.
- The review analyzed 31 articles from reputable databases and identified several potential biomarkers, including acute phase proteins, nociceptive neuropeptides, and stress hormones that are linked to lameness.
- While some metabolites show promise in identifying cows at risk for lameness, more research is needed, and practical application is complicated due to the invasive nature of the procedures often required for testing.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!