Concentrations of total proteins, albumin, total serum immunoglobulins, urea and total lipids in the blood serum and glucose concentrations in the blood were investigated in the periods of milk nutrition and weaning, and the results were evaluated with respect to their differences from the range of reference values. Concentrations of total proteins (TP) in the blood serum significantly decreased if the starting values at the age of two weeks (65, 45 g/l) were compared with the values at the age of five weeks, and they began to increase to the age of 11 weeks. The average TP values at the age of 11 weeks were significantly higher (p < 0.01) than the starting values (Fig. 1, Tab. I). TP concentrations were above the upper limit of the reference range since weaning (nine weeks of age). Subnormal TP values were recorded in individual animals at the age of two, five weeks, at weaning, at 11 weeks in the animals on all-vegetable diet in 4.8%, 19.1%, 4.8% and 9.5% of the calves, respectively (Fig. 2). The albumin concentrations were increasing from the age of five weeks but the changes in the values were statistically insignificant and the average values remained in the reference range (Fig. 1). The reduced albumin concentrations were recorded in individual animals in 28.6% of the calves at the age of two weeks, in 19.1% of the calves at the age of five weeks, in 42.9% of the calves at weaning, and in 38.1% at the age of 11 weeks. The concentrations of total serum immunoglobulins (TS-Ig) were increasing since the animal collection with their growing age (Fig. 1) while in comparison with the starting values the increases were significant at the age of five weeks (p < 0.05), nine and eleven weeks (p < 0.01). The average TS-Ig values rose to the reference range at the age of five weeks. In individual animals, the reduced TS-Ig values were recorded in the serum at the age of two weeks in 71.4% of calves, at the age of five weeks in 42.9%, at weaning in 33.3% and at the age of 11 weeks it was only in 9.5% of the calves (Fig. 2). The urea concentration in the serum was decreasing from the age of five weeks to weaning. In comparison with the starting values, the differences in the average values were statistically insignificant and the average values remained within the reference range (Fig. 1).(ABSTRACT TRUNCATED AT 400 WORDS)
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JAMA Neurol
January 2025
Department of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore.
Importance: Biomarkers would greatly assist decision-making in the diagnosis, prevention, and treatment of chronic pain.
Objective: To undertake analytical validation of a sensorimotor cortical biomarker signature for pain consisting of 2 measures: sensorimotor peak alpha frequency (PAF) and corticomotor excitability (CME).
Design, Setting, And Participants: This cohort study at a single center (Neuroscience Research Australia) recruited participants from November 2020 to October 2022 through notices placed online and at universities across Australia.
J Orthop Traumatol
January 2025
Unità Operativa di Ortopedia e Traumatologia, APSS Trento, Largo Medaglie d'oro, 9, 38121, Trento, Italy.
Background: The Masquelet induced membrane technique is a surgical procedure that allows the reconstruction of segmental bone defects using a relatively simple approach that requires minimal resources from both the healthcare facility and the patient. Historically applied to the lower limb, this technique is gaining increasing attention in the literature for its use in the upper limb.
Methods: A systematic review of the literature was conducted using the PubMed and Google Scholar databases to identify all studies reporting the outcomes of the Masquelet induced membrane technique in the long bones of the upper limb (humerus, radius, and ulna) with a sample size of at least 3 patients.
AIDS Behav
January 2025
Guangzhou Center for Disease Control and Prevention, Baiyun District, No. 1 Qide Road, Guangzhou, 510440, China.
This study examines the impact of HIV post-exposure prophylaxis (PEP) on sexual behavior changes in men who have sex with men (MSM), aiming to assess a comprehensive HIV prevention strategy integrating biomedical and behavioral interventions to maximize PEP service effectiveness. From a Guangzhou MSM cohort, participants without prior PEP experience were included. The exposed group received PEP services during follow-up (June 2019-April 2022), while controls did not.
View Article and Find Full Text PDFJ Diabetes Investig
January 2025
Göztepe Prof. Dr. Süleyman Yalçın City Hospital, Istanbul Medeniyet University, İstanbul, Turkey.
Aims: Growth differentiation factor-15 (GDF-15) is an inflammatory cytokine that increases in prediabetes and is known for its anorexigenic effects. This study aims to evaluate the effects of a 12-week exercise program on GDF-15 in individuals with prediabetes.
Materials And Methods: In this multicenter, parallel-group, randomized-controlled trial, 64 patients aged 18-60 diagnosed with prediabetes were randomized in a 1:1 ratio into the exercise group (E) and the control group (C).
Birth Defects Res
February 2025
Translational Research Division, Chugai Pharmaceutical Co. Ltd., Chuo, Japan.
Background: Nemolizumab, a humanized monoclonal antibody against interleukin-31 receptor A (IL-31RA), is used to treat atopic dermatitis and prurigo nodularis. These inflammatory skin diseases affect a wide range of age groups, including pregnant women and children; however, little is known about their biological effects on pre- and postnatal development. Therefore, we report and discuss the results of an enhanced pre- and postnatal development study in cynomolgus monkeys treated with nemolizumab, which also incorporates an assessment of juvenile toxicities.
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