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Altered IL-6 signalling and risk of tuberculosis: a multi-ancestry mendelian randomisation study.
Lancet Microbe
January 2025
Division of Infection and Immunity, University College London, London, UK. Electronic address:
Article Synopsis
- The study investigates the relationship between IL-6 signaling, particularly through the SNP rs2228145, and the risk of developing tuberculosis (TB), considering that inhibitors of IL-6 signaling might increase TB progression risk.
- The researchers conducted a meta-analysis of various genome-wide association studies (GWAS) to analyze genetic data and extract effect estimates related to the C allele of rs2228145, which is associated with reduced IL-6 signaling.
- Preliminary findings include data from 17 GWAS, covering a substantial sample of individuals with tuberculosis and a large control population, aiming to understand how genetic factors might influence TB susceptibility.
Anabolic Sensitivity in Healthy, Lean, Older Men Is Associated With Higher Expression of Amino Acid Sensors and mTORC1 Activators Compared to Young.
J Cachexia Sarcopenia Muscle
February 2025
Department of Physiology, Nutrition and Biomechanics, The Swedish School of Sport and Health Sciences, Stockholm, Sweden.
Article Synopsis
- Sarcopenia, the age-related loss of muscle mass, may stem from anabolic resistance and disrupted cellular signaling, but it's uncertain if aging alone causes these issues or if other factors play a role.!* -
- In a study with lean young men (average age 22) and old men (average age 70), participants performed resistance exercise followed by essential amino acid intake, with muscle biopsies taken at several intervals to measure amino acid levels and muscle protein synthesis (MPS).!* -
- Results showed both age groups had similar peak amino acid levels after exercise, but older individuals had heightened anabolic signaling in resting muscles, suggesting age may affect muscle recovery differently despite comparable exercise responses.!*
Heart Failure Awareness Survey in a Turkish Population: HFAS-TR.
Turk Kardiyol Dern Ars
July 2024
Department of Cardiology Ege University Faculty of Medicine, İzmir, Türkiye.
Objective: Heart failure is a leading cause of death and the most common diagnosis leading to hospitalization. Its awareness is lower than that of other cardiovascular diseases, both in the general population and among patients with heart failure (HF). This study aimed to establish the current level of knowledge about HF in patients with HF with reduced ejection fraction (HFrEF) and mildly reduced ejection fraction (HFmrEF) in Türkiye.
View Article and Find Full Text PDFInternational Criteria for Reporting Study Quality for Sudden Cardiac Arrest/Death Tool.
J Am Heart Assoc
June 2024
Department of Family Medicine, Center for Sports Cardiology University of Washington Seattle WA.
Background: Studies reporting on the incidence of sudden cardiac arrest and/or death (SCA/D) in athletes commonly lack methodological and reporting rigor, which has implications for screening and preventative policy in sport. To date, there are no tools designed for assessing study quality in studies investigating the incidence of SCA/D in athletes.
Methods And Results: The International Criteria for Reporting Study Quality for Sudden Cardiac Arrest/Death tool (IQ-SCA/D) was developed following a Delphi process.
Extracellular Matrix Protein-1 as a Mediator of Inflammation-Induced Fibrosis After Myocardial Infarction.
JACC Basic Transl Sci
December 2023
Department of Internal Medicine and University Heart Center, Division of Cardiology, Medical University of Graz, Graz, Austria.
Irreversible fibrosis is a hallmark of myocardial infarction (MI) and heart failure. Extracellular matrix protein-1 (ECM-1) is up-regulated in these hearts, localized to fibrotic, inflammatory, and perivascular areas. ECM-1 originates predominantly from fibroblasts, macrophages, and pericytes/vascular cells in uninjured human and mouse hearts, and from M1 and M2 macrophages and myofibroblasts after MI.
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