Estimation of serum copper and zinc was carried out on 40 Schistosoma mansoni patients with and without hepatosplenic involvement (group A and B respectively) before and after single oral dose of 40 mg praziquantel therapy as well as 20 normal controls (group C). Full clinical examination and assessment of liver function tests was done. HBsAg positive cases were excluded. The results showed a significant increase in the copper level in both groups (A and B) before treatment when compared to normal controls, and a significant reduction in zinc level only in group B. Following praziquantel therapy the copper level decreased with concomitant increase in the serum zinc level.
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