Fifteen subjects made 450 judgments each by the method of magnitude estimation of dimethyl disulfide and hydrogen sulfide after prior exposure to various mixtures of them. Exposure to the same odorant clearly affected the perceived intensity of it (self-adaptation). By contrast, exposure to the other odorant showed at best a small effect (cross-adaptation). Consistent with this, adaptation to a mixture of the test odorant and another odorant is proportional to the amount of the test odorant in the mixture, and does not exceed that of self-adaptation. These results indicate that olfactory adaptation is specific and that the sense of smell is more robust than generally assumed.
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http://dx.doi.org/10.1068/p220103 | DOI Listing |
BMC Pulm Med
January 2025
Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, China.
Background: Cough variant asthma (CVA) is a specific type of asthma characterized by chronic cough as the sole or predominant symptom. Accurate diagnosis is crucial for effective treatment, yet bronchial provocation test is not always feasible in clinical settings. To identify independent predictors of CVA diagnosis, we developed a nomogram for predicting CVA.
View Article and Find Full Text PDFInt J Eat Disord
January 2025
Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA.
Background: Individuals with avoidant/restrictive food intake disorder (ARFID) self-report heightened sensitivity to taste and smell, but neither phenomenon has been systematically explored in the laboratory. We hypothesized that, compared to healthy controls (HC, n = 34), children, adolescents, and adults with full/subthreshold ARFID (n = 100; ages 9 to 23 years) would self-report heightened response to taste/smell stimuli and exhibit stronger bitter taste perception and heightened smell perception in performance-based tasks, and these differences would be especially prominent in those with the ARFID-sensory sensitivity presentation.
Method: We measured self-reported sensitivity to taste/smell with the adolescent/adult sensory profile (AASP).
Int Forum Allergy Rhinol
January 2025
Division of Division of Rhinology & Skull Base Surgery Department of Otolaryngology, University of Florida, Gainesville, Florida, USA.
Rationale: Smoking has been shown to be associated with circulating deficiencies in 25(OH)D3 and reduced sinonasal tissue levels of the active form of vitamin D, 1,25(OH)2D3. Given vitamin D's ability to reduce inflammation, we sought to examine if intranasal (IN) delivery of calcitriol [clinical analog of 1,25(OH)2D3] could reduce inflammation and improve disease severity in a murine model of chronic cigarette smoke-induced sinonasal inflammation (CS-SI).
Methods: Mice were exposed to CS 5 h/day, 5 days/week for 9 months, and then began IN calcitriol three times per week for 4 weeks.
Anal Chim Acta
February 2025
School of Physics and Electronic Information Engineering, Henan Polytechnic University, Jiaozuo, 454003, China. Electronic address:
Background: Trimethylamine (TMA) is a colorless, volatile gas with a strong irritating odor. Prolonged exposure to a certain amount of TMA can cause symptoms such as dizziness, nausea and difficulty breathing, and may even be life-threatening. Therefore, effective detection of TMA is crucial.
View Article and Find Full Text PDFCell Rep
January 2025
Department of Cell Biology and Anatomy, LSUHSC, New Orleans, LA 70112, USA; Southeast Louisiana VA Healthcare System, New Orleans, LA 70119, USA. Electronic address:
Stress can alter behavior and contributes to psychiatric disorders by regulating the expression of the GluA2 AMPA receptor subunit. We have previously shown in mice that exposure to predator odor stress elevates GluA2 transcription in cerebellar molecular layer interneurons (MLIs), and MLI activity is required for fear memory consolidation. Here, we identified the critical involvement of adenylyl cyclase 5, in both the stress-induced increase in GluA2 in MLIs and the enhancement of fear memory.
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