Three patients were reinspected by ureteroscopy after repeat ESWL. Ureteroscopy initially did not disclose an intraluminal stone and only visualized a severe inflammatory reaction of the ureteric wall and a boss of the ureter at the level of the fluoroscopically suspected stone location. An intact stone in all 3 cases was finally exposed by tactile contact at the top of the ureteroscope after perforating the mucosa with a guide wire. Retrospectively, the combination of long-standing stone impaction together with damage to the ureteric mucosa during shockwave interaction may cause an inflammatory reaction with submucosal migration of the stone.
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http://dx.doi.org/10.1159/000282467 | DOI Listing |
Mol Med
December 2024
School of Respiratory Therapy, Taipei Medical University College of Medicine, 250 Wu-Hsing Street, Taipei, 11031, Taiwan.
Background: Mast cells are implicated in the pathogenesis and severity of asthma in children and adults. The release of proinflammatory mediators and cytokines from activated mast cells (MC) is associated with Type 2 (T2) cell-skewed inflammation.
Methods: We obtained the airway tissues of Balb/c mice with or without intra-tracheal diesel exhaust particles (DEP) instillation to measure the extent of tryptase MCs infiltration and interleukin (IL)-33 expression.
Int J Surg
December 2024
Department of Plastic Surgery and Burns, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China.
Background And Aims: Endoscopic submucosal dissection (ESD) is a pivotal technique for excision of early-stage esophageal tumors. However, its primary complication, postoperative esophageal stricture, is a significant challenge owing to the absence of effective preventive measures. Adipose-derived stem cells (ADSCs) have emerged as a promising treatment modality to address this concern.
View Article and Find Full Text PDFBiomolecules
October 2024
Department of Immunology, Xiangya School of Medicine, Central South University, Changsha 410078, China.
The abnormal proliferation and differentiation of oral mucosal fibroblasts (FBs) is the key to the progression of oral submucosal fibrosis. To clarify the mechanism of platelet-derived growth factor (PDGF-BB)-induced FBs fibrosis in oral mucosa, real-time quantitative polymerase chain reaction and Western blot were used in this study to detect the expression of miR-503 and the expression of p-MEK, p-ERK, miR-503, RAF, smooth actin and type I collagen under different time and concentration stimulation of PDGF-BB. The effects of overexpression of miR-503 or RAF on the proliferation and migration of FBs were detected by cell counting kit 8 and cell scratch assay, respectively.
View Article and Find Full Text PDFNurs Crit Care
October 2024
Intensive Care Unit, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China.
Glycobiology
August 2024
Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, United States.
Human sialic acid-binding immunoglobulin-like lectins (Siglecs) are expressed on subsets of immune cells. Siglec-8 is an immune inhibitory Siglec on eosinophils and mast cells, which are effectors in allergic disorders including eosinophilic esophagitis. Inhibition occurs when Siglec-8 is crosslinked by multivalent Siglec ligands in target tissues.
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