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Individual and combined effects of noise exposure and diabetes mellitus on hearing.
Noise Health
January 2025
School of Public Health, Southern Medical University, Guangzhou 510515, China.
Hearing loss (HL) is a prevalent health concern with a significant impact on society and the economy. Several factors contribute to the development of hearing impairment, with noise overexposure being the primary culprit. Diabetes mellitus (DM) is also a factor in hearing impairment, and studies have shown a positive correlation between DM and HL; however, the exact causal relationship and pathogenesis remain contentious.
View Article and Find Full Text PDFCascades Towards Noise-Induced Transitions on Networks Revealed Using Information Flows.
Entropy (Basel)
December 2024
Institute of Informatics, University of Amsterdam, 1098 XH Amsterdam, The Netherlands.
Complex networks, from neuronal assemblies to social systems, can exhibit abrupt, system-wide transitions without external forcing. These endogenously generated "noise-induced transitions" emerge from the intricate interplay between network structure and local dynamics, yet their underlying mechanisms remain elusive. Our study unveils two critical roles that nodes play in catalyzing these transitions within dynamical networks governed by the Boltzmann-Gibbs distribution.
View Article and Find Full Text PDFAbstractTheoretical studies from diverse areas of population biology have shown that demographic stochasticity can substantially impact evolutionary dynamics in finite populations, including scenarios where traits that are disfavored by natural selection can nevertheless increase in frequency through the course of evolution. Here, we analytically describe the eco-evolutionary dynamics of finite populations from demographic first principles. We investigate how noise-induced effects can alter the evolutionary fate of populations in which total population size may vary stochastically over time.
View Article and Find Full Text PDFConditional Tnfaip6-Knockout in Inner Ear Hair Cells Does not Alter Auditory Function.
Neurosci Bull
December 2024
Department of Otolaryngology-Head and Neck Surgery, Jiangsu Provincial Key Medical Discipline (Laboratory), Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China.
Noise-induced hearing loss is a worldwide public health issue that is characterized by temporary or permanent changes in hearing sensitivity. This condition is closely linked to inflammatory responses, and interventions targeting the inflammatory gene tumor necrosis factor-alpha (TNFα) are known to mitigate cochlear noise damage. TNFα-induced proteins (TNFAIPs) are a family of translucent acidic proteins, and TNFAIP6 has a notable association with inflammatory responses.
View Article and Find Full Text PDFThe potential of mitochondrially-targeted tetrapeptide in protecting against noise-induced hearing impairment.
Neuroreport
February 2025
Department of Otolaryngology, Case Western Reserve University, University Hospitals Cleveland Medical Center.
Noise-induced hearing loss (NIHL) constitutes a significant global health issue for which there is no effective treatment. The loss of cochlear hair cells and associated synaptopathy are common causes of hearing impairment. One primary mechanism implicated in NIHL is the accumulation of reactive oxygen species (ROS), which ultimately overwhelms cochlear cells.
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