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Revisiting surfactant protein D: an immune surveillance molecule bridging innate and adaptive immunity.
Front Immunol
January 2025
Department Integrative Agriculture, College of Agriculture and Veterinary Medicine, United Arab Emirates University, Al Ain, United Arab Emirates.
Surfactant protein D (SP-D) is a C-type lectin that was originally discovered as a lung surfactant associated phospholipid recognising protein. It was originally shown to be of great importance in surfactant turnover and homeostasis in conjunction with another hydrophilic surfactant protein i.e.
View Article and Find Full Text PDFChromosomal instability (CIN) is common in solid tumours and fuels evolutionary adaptation and poor prognosis by increasing intratumour heterogeneity. Systematic characterization of driver events in the TRACERx non-small-cell lung cancer (NSCLC) cohort identified that genetic alterations in six genes, including FAT1, result in homologous recombination (HR) repair deficiencies and CIN. Using orthogonal genetic and experimental approaches, we demonstrate that FAT1 alterations are positively selected before genome doubling and associated with HR deficiency.
View Article and Find Full Text PDFLong-term application of MC903 in mice prolongs the characteristic symptoms of atopic dermatitis, such as inflammation, skin barrier dysfunction, and itching.
Exp Anim
December 2024
Immunology and Allergy Laboratory, Immunology Unit, Department of Medical Innovations, Osaka Research Center for Drug Discovery, Otsuka Pharmaceutical Co., Ltd.
Atopic dermatitis (AD) is a chronic skin disease that causes itching and is characterized by recurrent flares and remissions. The interactions among type 2 inflammation, skin barrier dysfunction, and pruritus play important roles in the pathogenesis of AD. AD symptoms persist for a long period; thus, it is desirable to have disease models that reproduce a prolonged AD-like phenotype.
View Article and Find Full Text PDFFood Allergy Genetics and Epigenetics: A Review of Genome-Wide Association Studies.
Allergy
January 2025
Division of Dermatology, Department of Medicine, Queen's University, Kingston, Ontario, Canada.
Article Synopsis
- The review covers the genetic and epigenetic factors related to food allergies, including their inheritance and the advantages and limitations of study methods.
- Genome-wide association studies have identified 16 significant genetic variants linked to food allergies, often overlapping with other allergic conditions.
- The article emphasizes the importance of integrating genetic and epigenetic data for understanding disease mechanisms and suggests future implications for predicting food allergy risks and responses to treatment.
Blomia tropicalis: A 50-Year History.
J Allergy Clin Immunol Pract
November 2024
Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine, Tampa, Fla.
Article Synopsis
- * The discovery of 26 B. tropicalis allergens, some cross-reactive with other mite species, complicates diagnosis and treatment options for allergies, though advancements in component-resolved diagnostics aid in this process.
- * Immunotherapy using B. tropicalis extracts is effectively implemented in various countries, but there is a challenge with the limited availability of standardized extracts, despite significant research contributions over the past five decades on allergen characterization and potential impacts of climate change.
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