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An analysis is made of the hepatopathies characteristic of pregnancy according to the latest research and from experience of the Pathology Department of the Hospital Central of San Luis Potosí. Such entities are the fatty liver, the hyperemesis gravidarum, the preeclampsia and eclampsia and the cholestasis of pregnancy. It is estimated that the eclamptic state is capable of showing clinical, structural and laboratory manifestations which vary absolutely and which bring us to consider as dependent upon the fatty liver, the HELLP syndrome and some cases of cholestasis. Also, cholestasis of pregnancy, determined genetically, must be distinguished from that which is associated with eclampsia or determined by drugs or other causes. Similarly, hyperemesis gravidarum may be primary, although rarely so, or be due to neurological causes; it is also capable of causing slight liver dysfunction. Finally, the above-mentioned ailments are correlated within the classic physiopathological grid of jaundice.
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Atherosclerosis
March 2025
Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
Background/purpose: A new disease name, "Steatotic Liver Disease (SLD)" was proposed in 2023. Within this algorithm, combined metabolic and alcoholic liver disease (MetALD) was named as a new specific subgroup. The clinical profiles and outcomes of MetALD patients are unknown.
View Article and Find Full Text PDFLipids Health Dis
March 2025
Department of Critical Care Medicine, Shenzhen Second People's Hospital, Shenzhen, China.
Background: The relationship between the triglyceride glucose (TyG) values and the development of diabetes in non-alcoholic fatty liver disease (NAFLD) patients is not yet well researched. This study aims to examine how the baseline TyG levels correlate with the incidence of new-onset diabetes in this specific cohort.
Methods: This cohort included 2,506 normoglycemic Japanese adults with NAFLD who underwent routine health check-ups at Murakami Memorial Hospital between 2004 and 2015.
Sci Rep
March 2025
Center for Reproductive Medicine, Traditional Chinese Medicine Hospital of Meishan, Meishan, 620010, China.
Studies have shown that postmenopausal women have more metabolic abnormalities than premenopausal women. No consensus exists on how serum uric acid (sUA) affects metabolism-associated fatty liver disease (MAFLD) in postmenopausal women.This prospective observational study examined this link using National Health and Nutrition Examination Survey (NHANES) 2017 to 2020 data.
View Article and Find Full Text PDFNutr Metab Cardiovasc Dis
February 2025
Biosciences Department, Institute of Health and Society, Federal University of São Paulo, Campus Baixada Santista, UNIFESP, Santos, São Paulo, Brazil. Electronic address:
Background And Aim: The low-carbohydrate high-fat (LCHF) diet lipids are often overlooked for obesity management. We hypothesized that unsaturated lipids enhance fatty acid metabolism, and influence obesity-related metainflammation.
Methods And Results: Male Swiss mice were fed an obesity-inducing diet for ten weeks.
Eur J Pharmacol
March 2025
Department of Pharmacology, College of Pharmacy, Shaqra University, Shaqra, 11961, Saudi Arabia. Electronic address:
The endoplasmic reticulum (ER) plays a fundamental role in maintaining cellular homeostasis by ensuring proper protein folding, lipid metabolism, and calcium regulation. However, disruptions to ER function, known as ER stress, activate the unfolded protein response (UPR) to restore balance. Chronic or unresolved ER stress contributes to metabolic dysfunctions, including insulin resistance, non-alcoholic fatty liver disease (NAFLD), and neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease.
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