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Hyphenated Centrifugal Microsolid Phase Extraction and Centrifugal Acceleration Thin-Layer Chromatography in a Single Device: An Innovative Approach to Perform Consecutive Extraction and Separation.
Anal Chem
December 2024
Department of Analytical Chemistry, Faculty of Chemistry, K.N. Toosi University of Technology, P.O. Box 16315-1618, 15418-49611 Tehran, Iran.
Article Synopsis
- A new method for extracting and separating compounds from complex mixtures was developed using a circular chip and centrifugal force, enhancing the efficiency of microsolid phase extraction and chromatography.
- The technique utilizes rice husk to create an effective sorbent for model drugs curcumin and phenazopyridine, and evaluates extraction factors using the one-variable-at-a-time method.
- Results showed strong correlations between analyte concentration and detection intensities, with low limits of detection and high recovery rates in urine samples, indicating the method's reliability and effectiveness.
Modeling Lewy body disease with triplication iPSC-derived cortical organoids and identifying therapeutic drugs.
Sci Adv
September 2024
Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Aggregated α-synuclein (α-SYN) proteins, encoded by the gene, are hallmarks of Lewy body disease (LBD), affecting multiple brain regions. However, the specific mechanisms underlying α-SYN pathology in cortical neurons, crucial for LBD-associated dementia, remain unclear. Here, we recapitulated α-SYN pathologies in human induced pluripotent stem cells (iPSCs)-derived cortical organoids generated from patients with LBD with gene triplication.
View Article and Find Full Text PDFRemoval of phenazopyridine from water, synthetic urine, and real sample by adsorption using graphene oxide: A DFT theoretical/experimental approach.
Chemosphere
September 2024
Research Group on Adsorptive and Catalytic Process Engineering (ENGEPAC), Federal University of Santa Maria, Av. Roraima, 1000-7, Santa Maria, RS, 97105-900, Brazil. Electronic address:
Herein, graphene oxide was used as the highly efficient phenazopyridine adsorbent from aqueous medium, synthetic, and human urine. The nanoadsorbent was characterized by different instrumental techniques. The adsorption capacity (1253.
View Article and Find Full Text PDFDiscovery of an antivirulence compound that targets the Staphylococcus aureus SaeRS two-component system to inhibit toxic shock syndrome toxin-1 production.
J Biol Chem
July 2024
Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada. Electronic address:
Menstrual toxic shock syndrome (mTSS) is a rare but severe disorder associated with the use of menstrual products such as high-absorbency tampons and is caused by Staphylococcus aureus strains that produce the toxic shock syndrome toxin-1 (TSST-1) superantigen. Herein, we screened a library of 3920 small bioactive molecules for the ability to inhibit transcription of the TSST-1 gene without inhibiting the growth of S. aureus.
View Article and Find Full Text PDFSequence similarity network analysis of drug- and dye-modifying azoreductase enzymes found in the human gut microbiome.
Arch Biochem Biophys
July 2024
Department of Chemistry and Biochemistry, Providence College, 1 Cunningham Square, Providence, RI, 02918, United States. Electronic address:
Drug metabolism by human gut microbes is often exemplified by azo bond reduction in the anticolitic prodrug sulfasalazine. Azoreductase activity is often found in incubations with cell cultures or ex vivo gut microbiome samples and contributes to the xenobiotic metabolism of drugs and food additives. Applying metagenomic studies to personalized medicine requires knowledge of the genes responsible for sulfasalazine and other drug metabolism, and candidate genes and proteins for drug modifications are understudied.
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