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Influence of metalloproteinase-3 (-1171 5A>6A) polymorphism on periportal fibrosis in patients with schistosomiasis mansoni, Pernambuco, Brazil.
Acta Trop
December 2024
Gastroenterology Department, Hospital das Clínicas/EBSERH - Federal University of Pernambuco - UFPE, Recife, Brazil.
Article Synopsis
- Schistosomiasis mansoni (SM) leads to periportal fibrosis (PPF) due to inflammation from parasite eggs, resulting in collagen and matrix protein buildup in the liver.
- The study involved 242 individuals infected with S. mansoni in Pernambuco, Brazil, assessing the link between MMP-3 gene polymorphism (-1171 5A>6A) and PPF, alongside various sociodemographic factors.
- Findings revealed no significant link between MMP-3 polymorphism and PPF; however, male gender and age over 41 were identified as predictors for the hepatosplenic form of the disease.
Osteopontin Promotes Cholangiocyte Secretion of Chemokines to Support Macrophage Recruitment and Fibrosis in MASH.
Liver Int
October 2024
Regeneration and Repair, Institute of Hepatology, Foundation for Liver Research, London, UK.
Background And Aims: Osteopontin (OPN) promotes the ductular reaction and is a major driver of chronic liver disease (CLD) progression. Although CLD is characterised by the accumulation of inflammatory cells including macrophages around the peri-portal regions, the influence of OPN on recruitment is unclear. We investigated the role of OPN in cholangiocyte chemokine production and macrophage recruitment by combining in vivo, in vitro, and in silico approaches.
View Article and Find Full Text PDFCirculating capsid-antibody-complexes (CACs) drive intrahepatic complement deposition and inform subclinical liver inflammation in chronic hepatitis B.
Antiviral Res
November 2024
Shanghai Public Health Clinical Centre, Fudan University, Shanghai, China; Faculty of Science and Technology, University of Canberra, Australia. Electronic address:
Article Synopsis
- Chronic infection with Hepatitis B Virus (HBV) leads to weak virus-specific T cell responses, complicating viral clearance while causing significant liver inflammation due to immune responses.
- A new assay developed for detecting HBV Capsid-Antibody Complexes (CACs) showed high accuracy in measuring these complexes in serum and linked them to increased liver inflammation and damage in chronic hepatitis B patients.
- The study provides strong evidence that CACs play a key role in complement-mediated liver injury, establishing a new factor to consider alongside existing clinical markers for monitoring inflammation in chronic hepatitis B.
Getting in the zone: Metabolite transport across liver zones.
Acta Physiol (Oxf)
November 2024
Tytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Article Synopsis
- * Blood enters the liver through the periportal zone, flows through the mid-zone, and exits via the pericentral zone, with metabolite transport being crucial for liver function and division of labor among these zones.
- * Recent advancements in technology have improved understanding of how metabolic processes are organized in different liver zones, despite ongoing challenges in studying them separately, particularly regarding signaling pathways and the effects of daily rhythms on liver function.
Non-invasive assessment of esophageal and fundic varices in patients with primary biliary cholangitis.
Eur Radiol
September 2024
Beijing Chaoyang Hospital, Beijing, China.
Objectives: The Baveno VII consensus recommends endoscopic screening for varicose veins in cases of liver stiffness measurement (LSM) ≥ 20 kPa or platelet count ≤ 150 × 10/L. Whether this approach was appropriate for patients with primary biliary cholangitis (PBC) remains uncertain. This study expanded the observed risk factors by adding analysis of ultrasound images as a non-invasive tool to predict the risk of esophageal or fundic varices.
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