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Routine use of genetic data in healthcare is much-discussed, yet little is known about its performance in epidemiological models including traditional risk factors. Using severe COVID-19 as an exemplar, we explore the integration of polygenic risk scores (PRS) into disease models alongside sociodemographic and clinical variables. PRS were optimized for 23 clinical variables and related traits previously-associated with severe COVID-19 in up to 450,449 UK Biobank participants, and tested in 9,560 individuals diagnosed in the pre-vaccination era.
View Article and Find Full Text PDFTranslation, cross-cultural adaptation and psychometric evaluation of the Serbian Ankylosing Spondylitis Quality of Life (ASQoL) Questionnaire (refers to r-axSpA) and its relations with disease activity and functional status indices.
J Patient Rep Outcomes
January 2025
Institute of Rheumatology, Belgrade, Serbia.
Objectives: To translate, cross-culturally adapt and validate the Serbian Ankylosing Spondylitis Quality of Life (ASQoL) questionnaire, e.g. according to the new nomenclature Radiographic-Axial Spondyloarthritis (r-axSpA), and to relate it to disease activity and functional status domains.
View Article and Find Full Text PDFAdvanced Care Planning for the Orthopaedic Patient.
J Bone Joint Surg Am
January 2025
Department of Orthopaedic Surgery, Warren Alpert Medical School, Brown University, Providence, Rhode Island.
➢ Advanced care planning most commonly refers to the act of planning and preparing for decisions with regard to end-of-life care and/or serious illness based on a patient's personal values, life goals, and preferences.➢ Over time, advanced care planning and its formalization through advanced directives have demonstrated substantial benefits to patients, their families and caregivers, and the larger health-care system.➢ Despite these benefits, advanced care planning and advanced directives remain underutilized.
View Article and Find Full Text PDFAssociation between self-stigma and self-compassion in patients with schizophrenia: A longitudinal study from hospital admission to first follow-up after discharge.
Jpn J Nurs Sci
January 2025
Department of Psychiatric Nursing, Tohoku University Graduate School of Medicine, Sendai-shi, Japan.
Aim: Self-stigma is a major factor preventing the recovery of individuals with schizophrenia. Psychosocial interventions can reduce self-stigma, and mental health nurses may play a crucial role in leading them, but little is known about the modifiable factors that should be targeted. We aimed to investigate the association between self-stigma and self-compassion in patients with schizophrenia from admission to the first follow-up after discharge.
View Article and Find Full Text PDFRecommendations for Specialty Palliative APRN Graduate Education.
Nurse Educ
November 2024
Author Affiliations: Palliative Care Catalyst Network (Ms Dahlin), Beverly, Massachusetts, Palliative Care Services (Ms Dahlin), Mass General Brigham-Salem Hospital, Salem, Massachusetts; Meyers College of Nursing (Dr Wholihan), New York University, New York, New York; School of Nursing (Dr Wiencek), Loyola University, New Orleans, Louisiana; College of Nursing (Dr Acker), University of Alabama Capstone, Tuscaloosa, Alabama; College of Nursing (Dr Breakwell), Marquette University, Milwaukee, Wisconsin; School of Nursing (Ms Buschman), Columbia University, New York, New York; College of Nursing (Dr Cormack), Medical University of South Carolina, Charleston, South Carolina; College of Nursing (Dr DeSanto-Madaya), University of Rhode Island, Providence, Rhode Island; School of Nursing (Dr Doherty), University of Pennsylvania, Philadelphia, Pennsylvania; School of Nursing (Dr Edwards), The University of Alabama at Birmingham, Birmingham, Alabama; School of Nursing (Dr English), University of Colorado Anschutz Medical Campus, Aurora, Colorado; School of Medicine and College of Nursing (Dr Fink), University of Colorado Anschutz Medical Campus, Aurora, Colorado; Interprofessional MSPC & Palliative Certificate Programs (Dr Goodnough), University of Colorado Anschutz Medical Campus, Aurora, Colorado; College of Nursing (Dr Lindell), Medical University of South Carolina, Charleston, South Carolina; Francis Payne Bolton School of Nursing (Dr Mazanec), Case Western Reserve University, Cleveland, Ohio; College of Nursing (Dr McHugh), Columbia University Irving Medical Center, New York, New York; School of Nursing (Dr Moore), University of Southern Alabama, Mobile, Alabama; College of Nursing (Dr Obrecht), University of Illinois Chicago, Chicago, Illinois; School of Nursing (Dr Pawlow), University of Pennsylvania, Philadelphia, Pennsylvania; Palliative Care Department (Dr Johnstone-Petty), Providence Alaska Medical Group, Anchorage, Alaska; College of Nursing (Dr Quinlin), The Ohio State University, Columbus, Ohio; and School of Nursing (Dr Tresgallo), Columbia University Irving Medical Center, New York, New York.
Background: Advanced practice registered nurses (APRNs) are essential to care for the growing number of individuals with advanced illness given the shortage of palliative care clinicians.
Problem: Graduate education for specialty practice palliative APRNs lacks consistency in structure, content, and standardization of specialty palliative APRN education.
Approach: A workgroup of expert palliative APRNs and graduate faculty conducted focused discussions and a literature review to develop consensus recommendations based on national palliative APRN competencies and aligned with the 8 core concepts of the AACN Essentials.
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