The killing kinetics of cefotaxime and fosfomycin, alone and in combination, against seven clinical isolates of penicillin-resistant pneumococci were studied. The antibiotics were tested at 1 x, 2 x and 4 x the MIC for each individual isolate. The results showed a synergic interaction of the two antibiotics for three of the seven strains. This strategy may be useful clinically.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/jac/31.1.105 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Genomic analysis of colistin and carbapenem resistant Klebsiella pneumoniae GC29.
Microb Pathog
February 2025
Centre for Excellence in Microbiome, Government of Kerala, Thiruvananthapuram, Kerala, India.
Objectives: This study aims to sequence and analyze a clinical strain of Klebsiella pneumoniae (GC29) focusing on its antibiotic resistance profiles, virulence traits, and evolutionary lineage. The goal is to provide insights into the challenges of combating multi-drug resistant K. pneumoniae and emphasize the necessity for targeted strategies to address this public health threat.
View Article and Find Full Text PDFAntimicrobial Resistance of for Uncomplicated Cystitis: Korean Antimicrobial Resistance Monitoring System.
Antibiotics (Basel)
November 2024
Department of Urology, Goldman Urologic Clinic, Seoul 05510, Republic of Korea.
Uncomplicated cystitis is a leading form of bacterial UTI; the most common causative bacterium worldwide is . This internet-based, prospective, multicenter, and national observational study aimed to report the antimicrobial resistance of in patients with uncomplicated cystitis through the use of the Korean Antimicrobial Resistance Monitoring System (KARMS) in 2023. Data for a total of 654 patients were retrieved from the KARMS database.
View Article and Find Full Text PDFA Comprehensive Study of Bacterial Etiological Agents in Sterile Body Fluids and Antimicrobial Susceptibility Patterns Among Hospitalized Patients at an Academic Medical Center in India.
Cureus
October 2024
Department of Microbiology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, IND.
Article Synopsis
- Background: Sterile body fluids should be free of microbes, but bacterial presence can cause serious infections, making quick detection and identification of pathogens vital for patient recovery.
- Objective: The study aimed to evaluate the occurrence of bacterial infections in various sterile body fluids from hospitalized patients, focusing on understanding antimicrobial resistance and identifying specific beta-lactamase producers among bacterial isolates.
- Results: In the study, 180 sterile fluid samples were tested, with 17.77% being culture-positive, predominantly isolating gram-negative bacteria, which showed a high resistance to certain antibiotics like cefoperazone-sulbactam while exhibiting sensitivity to gentamicin and fosfomycin. *
Multidrug-Resistant and Other Gram-Negative Species Isolated from Native Egyptian Chicken Carcasses.
Trop Med Infect Dis
September 2024
Department of Food Hygiene, Safety, and Technology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt.
Poultry carcasses may be reservoirs for the zoonotic transmission of antimicrobial-resistant bacteria to humans and pose a major public health hazard. During the isolation of from poultry and other foods, many of the presumptive typical colonies on xylose lysine deoxycholate (XLD) agar were found to lack the gene, which is the specific target gene for spp. Therefore, the current study aimed to estimate the prevalence and antimicrobial resistance profiles of extensively drug-resistant -negative non- isolates recovered from native Egyptian chicken carcasses as presumptive colonies on XLD agar.
View Article and Find Full Text PDFPharmacokinetics of ceftriaxone, gentamicin, meropenem and vancomycin in liver cirrhosis: a systematic review.
J Antimicrob Chemother
November 2024
Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands.
Objectives: Patients with liver cirrhosis are prone to develop severe bacterial infections. Pharmacokinetics (PK) of antibiotics in cirrhosis are potentially affected by impaired biotransformation phases 0-3 and consequences of portal hypertension such as portovenous shunting, ascites formation and/or acute kidney injury (AKI). We aimed to elucidate to what extent PK of selected antibiotics and, therefore, dosage recommendations are affected in adults with cirrhosis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!