Representatives of different groups of antibiotics were tested on the autochtonous Escherichia coli of mice being in biofilm mode of growth, as well as on their isolates in planktonic phase. Aminoglycoside antibiotics, chloramphenicol, oxytetracycline, erythromycin, lincomycin-clindamycin, and polymyxins showed a very reduced effectivity on Escherichia coli embedded in the biofilm matrix. On the other hand, beta-lactam antibiotics were equally effective both for sessile and planktonic bacteria. Derivates with broader, or broad spectra showed an increased biofilm activity. Testing the possibilities of penetration or concentration on mouse colonic pieces exposed to 2 Minimal Bactericidal Doses--polymyxin B showed no sign of penetration into the colonic mucus, while 2.9% of streptomycin and 60% of the exposed quantity of carbenicillin was detected in the intestinal mucus. Ampicillin, however, has concentrated about three-four times in the intestinal matrix.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Spectroscopic aspects of underwater digital holography of plankton.
Sci Rep
January 2025
Laboratory for Radiophysical and Optical Methods of Environmental Research, National Research Tomsk State University, Tomsk, Russia, 634050.
Monitoring the parameters and behavior of plankton makes it possible to assess the state of the aquatic ecosystem and detect the beginning of an environmental disaster at an early stage. In this respect, the most informative method for the in situ plankton study is underwater digital holography. This method allows obtaining information on the size, shape, and location of plankton individuals, as well as performing their classification and biotesting according to their behavioral responses using a submersible holographic camera non-invasively, in real time, and in the automatic mode.
View Article and Find Full Text PDFExploring the intricate studies on low-density polyethylene (LDPE) biodegradation by Bacillus cereus AP-01, isolated from the gut of Styrofoam-fed Tenebrio molitor larvae.
Biodegradation
January 2025
Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai, Tamilnadu, 608502, India.
Article Synopsis
- The study investigates how well a gut bacteria strain, Bacillus cereus AP-01, can break down low-density polyethylene (LDPE), using experiments over 28 days to measure its effectiveness.
- The researchers employed various methods like FTIR and SEM to analyze changes in LDPE structure and confirmed the bacterial strain through molecular characterization.
- Results showed that the bacteria significantly degraded LDPE, with a 30.3% weight loss and changes in mechanical properties, highlighting its potential as a solution for plastic pollution.
Zingerone effect against Candida albicans growth and biofilm production.
J Mycol Med
December 2024
Department of Stem Cell and Regenerative Medicine and Medical Biotechnology, Centre for Interdisciplinary Research, DY Patil Education Society (Deemed to be University), Kolhapur, Maharashtra, 416003, India. Electronic address:
Background: The increasing resistance of Candida albicans biofilms underscores the urgent need for effective antifungals. This study evaluated the efficacy of zingerone and elucidated its mode of action against C. albicans ATCC 90028 and clinical isolate C1.
View Article and Find Full Text PDFLinking selection to demography in experimental evolution of active death in a unicellular organism.
Proc Biol Sci
December 2024
CEFE, University of Montpellier, CNRS, EPHE, IRD, Montpellier, France.
Deciphering how natural selection emerges from demographic differences among genotypes, and reciprocally how evolution affects population dynamics, is key to understanding population responses to environmental stress. This is especially true in non-trivial ecological scenarios, such as programmed cell death (PCD) in unicellular organisms, which can lead to massive population decline in response to stress. To understand how selection may operate on this trait, we exposed monocultures and mixtures of two closely related strains of the microalga , one of which induces PCD, to multiple cycles of hyper-osmotic shocks, and tracked demography and selection throughout.
View Article and Find Full Text PDFAlmond Hull Extract Valorization: From Waste to Food Recovery to Counteract and in Formation and Mature Biofilm.
Foods
November 2024
Fidia Farmaceutici SpA, Local Noto Unit Contrada Pizzuta, 96017 Noto, Italy.
The increase in food waste accumulation needs innovative valorization strategies that not only reduce environmental impacts but also provide functional applications. This study investigates the potential of almond hulls, an abundant agricultural by-product, as a source of bioactive compounds. For the first time, almond hull extract (AHE), was evaluated in terms of anti-adhesive and anti-biofilm activity against ATCC 29213 and ATCC 9637.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!