AI Article Synopsis
- The study aimed to create a new method for delivering drugs directly to the angular aqueous plexus/Schlemm's canal (AAP/SC), bypassing the trabecular meshwork to better understand its function.
- Methods involved creating a small negative pressure in the anterior chamber, allowing fluid to flow retrograde from limbal vessels into the AAP/SC while analyzing results through various studies in bovine eyes.
- Key findings showed that retroperfusion did not change the outflow pathways significantly but indicated that it could increase washout rates and cause breaks in the AAP/SC's inner wall, suggesting a potential mechanism for drug delivery.
Article Abstract
Purpose: The goal of this study was to develop a new technique to deliver drugs or other agents to the lumen of the angular aqueous plexus/Schlemm's canal (AAP/SC) while bypassing the trabecular meshwork, thereby gaining insight into AAP/SC inner wall function.
Methods: The anterior chamber is held at a small negative pressure and fluid is allowed to flow retrograde from the limbal vessels, through the collector channels, and into the AAP/SC ("retroperfusion"). Facility measurements are combined with histologic and tracer studies in bovine eyes.
Results: (1) Retroperfusion with a saline solution does not alter facility or change outflow pathway morphology; (2) fluid is able to move retrograde from the scleral surface and enter the lumen of the AAP; and (3) retroperfusion with N-ethyl maleimide causes a dose-dependent increase in washout rate and concomitant inner wall breaks.
Conclusions: It is hypothesized that the observed increase in washout is due to leakage of extracellular materials through breaks in the inner wall.
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