In cooperation with BAZIS (Support Group Hospital Information Systems at Leiden, The Netherlands), we started the design of a Picture Archiving and Communications System (PACS) a few years ago that contains a centralized image data base. By means of system modeling and measuring some performance parameters, we have discovered that such a system cannot provide the required response times. This is mainly because of equipment communications interfaces that are not fast enough and have a throughput that does not generally exceed 16 Mbits/second. By providing a parallel operating image buffer system, the problems related to the limited speed of the communication interfaces can be overcome. Moreover, by splitting the network into a number of subnets connected to each other by means of "bridges," the communications load can be locally reduced, improving in this manner the response times. Our PACS contains a supervisor and one relational data base that relates patient data with image locations. A significant part of the report is concerned with the design of the high speed American College of Radiology-National Electronic Manufacturing Association transmission control protocol/internet protocol (ACR-NEMA TCP/IP) communications interface. The use of such an interface eliminates the need for a Network Interface Unit, reducing in this manner communication delays and complexity. We have developed and have in operation for experimental purposes a small-scale PACS, consisting of a number of workstations, a relational data base and image buffers, all connected to a network that uses the ACR-NEMA TCP/IP protocols. This experimental PACS is used to provide input data to a PACS performance model, to validate this model, and to investigate alternative system configurations.
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http://dx.doi.org/10.1007/BF03168419 | DOI Listing |
J Hered
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Centro de Investigación de Estudios Avanzados del Maule, Universidad Católica del Maule, Avenida San Miguel 3605, Talca, Chile.
Mosquitoes from the Culex pipiens complex are found worldwide and have been the focus of numerous studies due to their role as vectors of human pathogens. We investigated the population genetic structure of Cx. pipiens s.
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Cornell Joan Klein Jacobs Center for Precision Nutrition and Health, Cornell University, Ithaca, NY, USA.
Background: Precision nutrition-based methods develop tailored interventions and/or recommendations accounting for determinants of intra- and inter-individual variation in response to the same diet, compared to current 'one-size-fits-all' population-level approaches. Determinants may include genetics, current dietary habits and eating patterns, circadian rhythms, health status, gut microbiome, socioeconomic and psychosocial characteristics, and physical activity. In this systematic review, we examined the evidence base for the effect of interventions based on precision nutrition approaches on overweight and obesity in children and adolescents to help inform future research and global guidelines.
View Article and Find Full Text PDFJ Chem Theory Comput
January 2025
Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States.
Despite its importance in understanding biology and computer-aided drug discovery, the accurate prediction of protein ionization states remains a formidable challenge. Physics-based approaches struggle to capture the small, competing contributions in the complex protein environment, while machine learning (ML) is hampered by the scarcity of experimental data. Here, we report the development of p ML (KaML) models based on decision trees and graph attention networks (GAT), exploiting physicochemical understanding and a new experiment p database (PKAD-3) enriched with highly shifted p's.
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Department of Pharmacy, Huadong Hospital, Fudan University, Shanghai, China.
Objective: Capivasertib, a novel pan-AKT inhibitor, shows significant antitumor activity against hormone receptor-positive advanced breast cancer. However, its cost-effectiveness of this treatment remains uncertain. This study aimed to evaluate the cost-effectiveness of capivasertib plus fulvestrant versus fulvestrant alone for advanced breast cancer treatment from the perspectives of healthcare payers in the United States.
View Article and Find Full Text PDFJ Neurol Surg B Skull Base
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Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Orbital apex syndrome (OAS) is characterized by visual loss, ophthalmoplegia, ptosis, and orbital pain. This study aims to analyze neuro-ophthalmologic outcomes of OAS resulting from invasive fungal rhinosinusitis (IFS). This retrospective study analyzed 25 patients diagnosed with OAS resulting from IFS between January 2018 and July 2022.
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