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Recombinant FOXN1 fusion protein increases T cell generation in old mice.
Front Immunol
July 2024
Department of Allied Health Sciences, University of Connecticut, Storrs, CT, United States.
T cell development in the thymus is dependent on the thymic microenvironment, in which thymic epithelial cells (TECs) are the major component. However, TECs undergo both a qualitative and quantitative loss during aging, which is believed to be the major factor responsible for age-dependent thymic atrophy. FOXN1 plays a critical role in TEC development and adult TECs maintenance.
View Article and Find Full Text PDFA model for preservation of thymocyte-depleted thymus.
Braz J Med Biol Res
August 2023
Fundação Pró-Sangue São Paulo, Hemocentro de São Paulo, São Paulo, SP, Brasil.
DiGeorge syndrome is a disorder caused by a microdeletion on the long arm of chromosome 22. Approximately 1% of patients diagnosed with DiGeorge syndrome may have an absence of a functional thymus, which characterizes the complete form of the syndrome. These patients require urgent treatment to reconstitute T cell immunity.
View Article and Find Full Text PDFBackground: Although the thymus continues to export T cells throughout life, it undergoes a profound involution/atrophy with age, resulting in decreased numbers of T cells in the older adult, which has direct etiological linkages with many diseases. T cell development in the thymus is dependent on the thymic microenvironment, in which thymic epithelial cells (TECs) are the major component. However, TECs undergo both a qualitative and quantitative loss during aging, which is believed to be the major factor responsible for age-dependent thymic atrophy.
View Article and Find Full Text PDFIntrathymic AAV delivery results in therapeutic site-specific integration at TCR loci in mice.
Blood
May 2023
San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Adeno-associated virus (AAV) vectors have been successfully exploited in gene therapy applications for the treatment of several genetic disorders. AAV is considered an episomal vector, but it has been shown to integrate within the host cell genome after the generation of double-strand DNA breaks or nicks. Although AAV integration raises some safety concerns, it can also provide therapeutic benefit; the direct intrathymic injection of an AAV harboring a therapeutic transgene results in integration in T-cell progenitors and long-term T-cell immunity.
View Article and Find Full Text PDFProtocol for standardized intrathymic injection in mice.
STAR Protoc
March 2023
Institute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taipei 112, Taiwan; Taiwan International Graduate Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei, Taiwan. Electronic address:
Article Synopsis
- Current intrathymic injection methods often lead to complications and have challenges in accessing the necessary equipment.
- This study introduces a standardized intrathymic injection protocol that is minimally invasive and only requires basic tools.
- It outlines how to locate injection sites for effective drug delivery and demonstrates the success of the procedure by using Indian ink in the injection solution.
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