A 44-year-old man with severe visual loss due to an acute bilateral sequential optic neuropathy is described, where the associated pulmonary disease and peripheral eosinophilia led to a diagnosis of Churg-Strauss syndrome (allergic angiitis). The mechanism of the optic neuropathy was most probably acute ischaemia of the anterior optic nerve due to direct involvement of the short posterior ciliary arteries by inflammatory disease of the vessel wall.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC504444PMC
http://dx.doi.org/10.1136/bjo.77.2.118DOI Listing

Publication Analysis

Top Keywords

optic neuropathy
12
severe visual
8
visual loss
8
bilateral sequential
8
sequential optic
8
churg-strauss vasculitis
4
vasculitis presenting
4
presenting severe
4
loss bilateral
4
optic
4

Similar Publications

GLP-1 receptor agonists in diabetes and weight loss: the double-edged sword of innovation and risks.

Front Clin Diabetes Healthc

January 2025

School of Medicine, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (Promise), University of Palermo, Palermo, Italy.

View Article and Find Full Text PDF

Objective: This study aimed to elucidate the clinical manifestations, laboratory findings and outcomes of patients with intravascular large B cell lymphoma (IVLBCL) with neurological involvement and to differentiate IVLBCL with and without neurological involvement.

Methods: A cohort study was conducted at Siriraj Hospital, Mahidol University, Thailand, between January 2005 and September 2024. Clinical data, laboratory values and central nervous system imaging results were analysed.

View Article and Find Full Text PDF

The optimal therapeutic intervention for pediatrics with optic pathway glioma (OPG) remained controversial in the literature. Recently, due to substantial adverse events (AEs) of chemotherapy and its impact on children's lives, the efficacy of other options has been investigated. Bevacizumab (BVZ) is an anti-vascular endothelial growth factor (VEGF) agent that alters the lesion microenvironment.

View Article and Find Full Text PDF

Purpose: The optic nerve (ON) is mechanically perturbed by eye movements that shift cerebrospinal fluid (CSF) within its surrounding dural sheath. This study compared changes in ON length and CSF volume within the intraorbital ON sheath caused by eye movements in healthy subjects and patients with optic neuropathies.

Methods: Twenty-one healthy controls were compared with 11 patients having primary open angle glaucoma (POAG) at normal intraocular pressure (IOP), and 11 with chronic non-arteritic anterior ischemic optic neuropathy (NA-AION).

View Article and Find Full Text PDF

In Vivo Imaging of Cobalt-Induced Ocular Toxicity in a Mouse Model.

Methods Protoc

January 2025

The Krieger Eye Research Laboratory, Bruce and Ruth Faculty of Medicine, Technion-Institute of Technology, Haifa 3525433, Israel.

Cobalt is a trace element, crucial for red blood cell formation and neurological function. Cobalt toxicity is often only diagnosed after severe manifestations, including visual impairment. We aimed to investigate whether optical coherence tomography (OCT) and magnetic resonance imaging (MRI) can effectively detect cobalt-induced ocular toxicity in a murine model.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!