AI Article Synopsis
- The study examined the shape and morphology of platelets in patients with thrombotic thrombocytopenic purpura (TTP), revealing that they take on a spineless sphere shape with no pseudopods, which lasts even after remission.
- The abnormal platelet shape is caused by prolonged activation of normal platelets through various agonists, except for ADP, and involves dysfunction in both microtubules and microfilaments.
- The detected PAF and PSCF activities in patient samples were not reliable indicators of TTP activity, suggesting that while the shape change is notable, it does not correlate directly with disease activity.
Article Abstract
The morphology of circulating platelets in thrombotic thrombocytopenic purpura (TTP) was studied, and basic mechanism of the characteristic shape abnormality found in TTP was investigated in in vitro condition. The platelet shape was spineless sphere (spherical platelets without pseudopods), and shape change persisted 2 months after remission. This type of platelets were produced by long term of activation of normal resting platelets by several agonists except ADP, and induced by dysfunction of both microtubules and microfilaments. These suggest that the shape change in TTP is not specific, but a good parameter for the activity of TTP. PAF activity by the method of Kelton et al. (1984) was detected in only 1 out of 30 samples from 10 patients. PSCF activity was found in 9 out of 29 samples from 10 patients independently from disease activity. Both activities does not reflect the activity of TTP.
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