Within the scope of the clinical evaluation of Tilmicosin in Enzootic Pneumonia of pigs, nasal swabs from 78 animals were taken, before and after oral medication of different doses (0, 100, 200, 300 mg Tilmicosin/kg dry food), and examined bacteriologically for Pasteurella multocida, Bordetella bronchiseptica und Haemophilus parasuis. The bacteria aforementioned were isolated from the nasal secretions of 83% of the pigs, 14 days after crowding without any prophylactic regime. It could be demonstrated, that pigs with clinical symptoms of Enzootic Pneumonia had a 50% higher prevalence-rate of multi-colonization with pneumotropic bacteria than healthy animals. Feeding 300 mg Tilmicosin/kg food for 9 and 14 days respectively, resulted in elimination of Pasteurella spp. and Haemophilus spp. The rate of newly Bordetella bronchiseptica infected pigs was lower than in the placebo-group. Parallel to these bacteriological results improvement of clinical signs and increased daily weight gain were observed.
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Front Vet Sci
January 2025
Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN, United States.
Background: Several epidemiological studies have been carried out using Multiple-Locus Variable-number tandem repeat Analysis (MLVA) for typing. However, a global perspective on the implications of the genetic diversity of this pathogen is lacking.
Objective: This study aimed to determine and to analyze the genetic structure of based on the R1-R3 MLVA typing scheme and to characterize, analyze and compare MLVA types among countries where the information was publicly available.
Pathogens
November 2024
The Davies Livestock Research Centre, School of Animal and Veterinary Sciences, University of Adelaide, Adelaide, Adelaide, SA 5005, Australia.
, an important cause of enzootic pneumonia in pigs in many countries, has recently been shown to exhibit reduced susceptibility to several antimicrobial classes. In the present study, a total of 185 pig lung tissue samples were collected from abattoirs in Australia, from which 21 isolates of were obtained. The antimicrobial resistance profile of the isolates was determined for 12 antimicrobials using minimum inhibitory concentration (MIC) testing, and a subset ( = 14) underwent whole-genome sequence analysis.
View Article and Find Full Text PDFVet Sci
November 2024
Australian Centre for Antimicrobial Resistance Ecology, Faculty of Sciences, Engineering and Technology, School of Animal and Veterinary Science, The University of Adelaide, Adelaide, SA 5005, Australia.
Antimicrobial resistance (AMR) in , the causative agent of Enzootic Pneumonia in swine, poses a significant challenge to the swine industry. This review focuses on the genetic foundations of AMR in , highlighting the complexity of resistance mechanisms, including mutations, horizontal gene transfer, and adaptive evolutionary processes. Techniques such as Whole Genome Sequencing (WGS) and multiple-locus variable number tandem repeats analysis (MLVA) have provided insights into the genetic diversity and resistance mechanisms of .
View Article and Find Full Text PDFVet Microbiol
December 2024
Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture and Rural Affairs, Nanjing, China; Guotai (Taizhou) Center of Technology Innovation for Veterinary Biologicals, Taizhou, China; College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China; School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China. Electronic address:
Mycoplasma hyopneumoniae (M. hyopneumoniae) is the causative agent of swine enzootic pneumonia, resulting in substantial economic losses in global pig farming. Although vaccination is the primary strategy for controlling M.
View Article and Find Full Text PDFMicroorganisms
September 2024
Swine Medicine Laboratory, School of Agricultural and Veterinary Sciences, São Paulo State University (Unesp), Jaboticabal 14884-900, Brazil.
() is the key pathogen of the porcine respiratory disease complex (PRDC) and contributes to pleurisy in pigs. Due to its limited metabolism and laborious cultivation, molecular tools are useful for diagnosis. This study investigated the genetic diversity of in slaughter pigs with pneumonia and pleurisy, and it assessed co-infections by type A (PM), (APP), and swine influenza virus A (sIVA).
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