Cerebral perfusion deficits detected by injection of 99Tcm-hexamethylpropyleneamine oxime (HMPAO) and single photon emission tomography is said to correlate well with clinical findings in divers with neurological decompression illness. We studied 12 divers. Six had residual cerebral signs (group 1) and six had no residual cerebral symptoms or signs (group 2). Perfusion deficits were as common in group 2 as in group 1. The site of the deficit did not correlate well with either the neurological findings at presentation or the residual clinical signs after treatment. The data suggest that claims that HMPAO scanning correlates with clinical findings and can be used for patients management were incorrect.
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http://dx.doi.org/10.1097/00006231-199302000-00008 | DOI Listing |
Neurology
January 2025
Leonard Davis School of Gerontology, University of Southern California, Los Angeles.
Background And Objectives: Cerebrovascular reactivity (CVR) represents the ability of cerebral blood vessels to regulate blood flow in response to vasoactive stimuli and is related to cognition in cerebrovascular and neurodegenerative conditions. However, few studies have examined CVR in the medial temporal lobe, known to be affected early in Alzheimer disease and to influence memory function. We aimed to examine whether medial temporal CVR is associated with memory function in older adults with and without mild cognitive impairment (MCI).
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December 2024
Department of Radiology, Northwestern University, Chicago, IL, USA.
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View Article and Find Full Text PDFAlzheimers Dement
December 2024
Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, Hainan, China.
Background: Quantitative transport mapping (QTM) has been developed for estimation of blood flow velocity with 4D dynamic tracer concentration data (Zhou et. al., Magn.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Texas A&M University Health, Bryan, TX, USA.
Background: Our studies show that the small non-coding RNA, mir20a-3p, is neuroprotective for stroke in the acute phase and also attenuates long term cognitive decline in middle-aged female rats. Cognitive decline due to vascular diseases, such as stroke, is associated with secondary neurodegeneration in cortex and limbic structures. In this study, we assessed the volume of white matter, ventricles and regional diffusion-weighted MR imaging measures to delineate pathological tissue characteristics from the postmortem brain of stroke rats.
View Article and Find Full Text PDFUltrasound Med Biol
January 2025
Biomedical Engineering, Cardiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands; Medical Imaging, Department of Imaging Physics, Faculty of Applied Sciences, Delft University of Technology, Delft, the Netherlands. Electronic address:
Objective: Assessing myocardial perfusion in acute myocardial infarction is important for guiding clinicians in choosing appropriate treatment strategies. Echocardiography can be used due to its direct feedback and bedside nature, but it currently faces image quality issues and an inability to differentiate coronary macro- from micro-circulation. We previously developed an imaging scheme using high frame-rate contrast-enhanced ultrasound (HFR CEUS) with higher order singular value decomposition (HOSVD) that provides dynamic perfusion and vascular flow visualization.
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