Widespread use of extracorporeal membrane oxygenation (ECMO) has allowed an increasing number of infants with total agenesis of the diaphragm to survive. Polytetrafluoroethylene (PTFE) is the most widely used material for reconstruction. However, recurrent hernia is a growing problem; PTFE also does not grow with the patient. This study evaluated different materials for diaphragmatic reconstruction in growing animals. Sprague-Dawley rats with a mean weight of 93 g were anesthetized and underwent laparotomy. The control group had an incision into the diaphragm with primary repair. The other three groups underwent complete removal of the left hemidiaphragm and were randomly assigned to one of three reconstruction methods: oxidized cellulose, polyglactin mesh, or a 1-mm PTFE patch. All patch materials were sewn around the ribs circumferentially and into the membranous portion of the central diaphragm medially with 4-0 silk. Thirty-seven animals survived operation, were followed with weekly chest radiographs, and were killed when they reached 400 g. The radiographs were reviewed in a blinded fashion by two observers as were the necropsies, and rib deformity was graded on a scale of 0 to 3. Histological examination of several animals from each group was performed. There was significantly greater rib deformity (2.0 v 0.2, P < .01) in the PTFE group versus controls with 5 of 10 animals also having a smaller thorax. The PTFE pulled away from the chest wall in the animals leaving a fibrous remnant anteriorly. The polyglactin group had significantly more animals with eventration (P < .03, 7/10) compared with all others.(ABSTRACT TRUNCATED AT 250 WORDS)
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0022-3468(05)80352-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Research progress of femoral head necrosis in HIV-infected patients.
Ann Med
December 2025
Department of Joint and Sports Medicine, Zhongnan Hospital, Wuhan University, Wuhan, China.
As life expectancy among patients infected with the human immunodeficiency virus (HIV) increases, a growing number of complications have been observed. This population displays an elevated risk of ischemic necrosis of the femoral head in comparison to the general population, which may be attributed to HIV infection, antiretroviral medication use, and hormone application. Patients infected with the human immunodeficiency virus (HIV) who also have necrosis of the femoral head tend to present at an earlier age, with a rapid disease progression and a high incidence of bilateral onset.
View Article and Find Full Text PDFResponse to: The Chaos in China's Aesthetic and Plastic Surgery Industry Urgently Needs to be Addressed.
Aesthetic Plast Surg
January 2025
Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128, Rome, Italy.
The proliferation of unlicensed aesthetic medical (UAE) practices in China's plastic surgery industry highlights a pressing global concern, amplified by the growing "beauty economy." Social media platforms perpetuate unattainable beauty standards through edited images and curated pre- and post-operative photos, fueling demand for aesthetic treatments and exacerbating body dysmorphic disorder (BDD). Vulnerable individuals targeted by manipulative advertising often fall victim to unsafe UAE services.
View Article and Find Full Text PDFGLP-1 Agonists in Plastic Surgery: Impact on Aesthetic Outcomes-Two Case Reports.
Aesthetic Plast Surg
January 2025
UOSD Chirurgia Plastica, Dipartimento per la Salute della Donna, del Bambino e di Sanità Pubblica - Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS - Università Cattolica del "Sacro Cuore", Largo A. Gemelli 8, 00168, Rome, Italy.
Background: Obesity is a growing global epidemic, with glucagon-like peptide-1 (GLP-1) receptor agonists emerging as effective pharmacological solutions for weight loss. However, these medications raise concerns in the context of aesthetic and reconstructive surgery due to their effects on wound healing, adipose tissue metabolism, and their potential impact on surgical outcomes.
Objective: To report two cases of delayed wound healing and fat necrosis in patients undergoing breast surgery while receiving GLP-1 receptor agonists for weight management.
Understanding the Lymphatic System: Tissue-on-Chip Modeling.
Annu Rev Biomed Eng
January 2025
1Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill and Raleigh, North Carolina, USA;
The lymphatic vasculature plays critical roles in maintaining fluid homeostasis, transporting lipid, and facilitating immune surveillance. A growing body of work has identified lymphatic dysfunction as contributing to the severity of myriad diseases and to systemic inflammation, as well as modulating drug responses. Here, we review efforts to reconstruct lymphatic vessels in vitro toward establishing humanized, functional models to advance understanding of lymphatic biology and pathophysiology.
View Article and Find Full Text PDFRed Breast Syndrome-Where Has It Gone?: A Systematic Review of Red Breast Syndrome Incidence Overtime.
Ann Plast Surg
February 2025
Division of Plastic & Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA.
Background: Red breast syndrome (RBS) has been noted in past literature as a possible complication of implant-based breast reconstruction (IBBR) with the use of acellular dermal matrices (ADMs). Since its first appearance in 2009, RBS has drawn growing medical attention with reported incidence ranging from 7%-9%. There has been a noted decrease in the emergence of RBS despite its inclusion among the analyzed complications in a number of studies.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!