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Non-dilated obstructive nephropathy.

Clin Kidney J

October 2024

Department of Surgical Sciences, Unit of Urology, Tor Vergata University Hospital, Rome, Italy.

Article Synopsis
  • - Obstructive nephropathy (ON) is a reversible condition that can cause acute kidney injury, resulting from blockage in the urinary tracts; it may not always present with hydronephrosis, leading to a form called non-dilated obstructive uropathy (NDOU).
  • - NDOU typically occurs in older males and can present symptoms like low urine output, abdominal pain, and high serum creatinine levels; it often stems from external ureter compression due to conditions like retroperitoneal fibrosis or tumors.
  • - Effective treatments include minimally invasive methods like ureteric stenting or nephrostomy, and timely diagnosis is crucial for managing the obstruction and potentially reversing kidney damage.
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Vesicoureteral reflux (VUR) is defined as the urine backflow from the urinary bladder to the pyelo-caliceal system. In contrast, intrarenal reflux (IRR) is the backflow of urine from the renal calyces into the tubulointerstitial space. VURs, particularly those associated with IRR can result in reflux nephropathy when accompanied by urinary tract infection (UTI).

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Background: Accurate measurement of ureteral diameters plays a pivotal role in diagnosing and monitoring urinary tract obstruction (UTO). While three-dimensional magnetic resonance urography (3D MRU) represents a significant advancement in imaging, the traditional manual methods for assessing ureteral diameters are characterized by labor-intensive procedures and inherent variability. In the realm of medical image analysis, deep learning has led to a paradigm shift, yet the development of a comprehensive automated tool for the precise segmentation and measurement of ureters in MR images is an unaddressed challenge.

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Background: A well-established definition of obstruction in the setting of congenital hydronephrosis is lacking. Multiple imaging modalities and radiographic characteristics or parameters have been described to help confirm the diagnosis of ureteropelvic junction obstruction (UPJO). We sought to evaluate the change in anterior-posterior renal pelvic diameter (APRPD) following furosemide administration in patients with unilateral hydronephrosis and confirmed UPJO on functional magnetic resonance urography (fMRU) who underwent pyeloplasty.

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Objectives: To identify the diagnostic performance of clinical and radiological signs (on voiding cystourethrography [VCUG]) to detect posterior urethral valves (PUV) in the post-neonatal period.

Materials And Methods: One hundred eighteen males (median age = 0.8 years, range = 1 month-14 years, 48 toilet-trained) undergoing VCUG in a 2-year period were prospectively enrolled.

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