AI Article Synopsis
- The study examined the role of platelets in bronchial asthma under three conditions: chronic asthma, house dust mite inhalation, and status asthmaticus.
- About one-third of asthma patients showed elevated beta-thromboglobulin (beta-TG) or platelet factor 4 (PF4), but significant differences were only found between healthy individuals and symptomatic patients.
- The results indicate that while platelet activation can occur in asthma, the levels of specific proteins in the blood do not accurately reflect the severity of the condition, suggesting that platelet-activating factor (PAF) may play a key role in this process.
Article Abstract
The possible involvement of platelets in bronchial asthma was investigated under three different conditions: (1) chronic asthma, (2) bronchial provocation inhaling house dust mite (HDM), and (3) status asthmaticus. Plasma levels of beta-thromboglobulin (beta-TG), platelet factor 4 (PF4), and in part, platelet-activating factor (PAF) were measured. Approximately one third of the subjects with symptomatic or asymptomatic chronic asthma showed an increased level of beta-TG or PF4. Statistically significant differences occurred in beta-TG and PF4 levels only between healthy controls and symptomatic subjects. Five out of six subjects showed no elevation of beta-TG and PF4 during immediate asthmatic response. In two out of nine subjects with status asthmaticus, beta-TG or PF4 was elevated, and statistically significant correlations occurred between the initial level of PAF and that of beta-TG or PF4. Those results suggest that the platelet activation in the circulation is sometimes provoked in asthma, but plasma level of alpha-granule-derived proteins does not reflect the intensity or severity of asthma, and that PAF is likely to be a mediator responsible for the platelet activation.
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| http://dx.doi.org/10.1016/0091-6749(93)90299-u | DOI Listing |
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