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Novel Technique for Biopsying Osteofibrous Dysplasia Using a Vacuum-assisted Bone Harvester: A Case Report.
J Orthop Case Rep
October 2024
Department of Orthopaedic Surgery, Duke University Hospital, Durham, North Carolina, United States.
Article Synopsis
- Osteofibrous dysplasia (OFD) is a rare, benign bone lesion primarily found in the tibia, characterized by the growth of fibrous tissue and variable bone involvement, making diagnosis challenging.
- A case study highlights a young patient with OFD-related pain and introduces a new vacuum-assisted bone harvester technique for more effective biopsy and curettage.
- This innovative method improves the ability for surgeons to obtain tissue samples and perform necessary procedures in cases of OFD.
A genetic mouse model mimicking MET related human osteofibrous dysplasia is characterized by delays in fracture repair and defective osteogenesis.
FASEB J
July 2024
Department of Medical Genetics, University of Alberta, Edmonton, Alberta, Canada.
Osteofibrous dysplasia (OFD) is a rare, benign, fibro-osseous lesion that occurs most commonly in the tibia of children. Tibial involvement leads to bowing and predisposes to the development of a fracture which exhibit significantly delayed healing processes, leading to prolonged morbidity. We previously identified gain-of-function mutations in the MET gene as a cause for OFD.
View Article and Find Full Text PDFEvaluation of subperiosteal hemicortical resection and bone grafting to treat tibial osteofibrous dysplasia in children.
J Pediatr Orthop B
January 2025
Department of Orthopedics, Children's Hospital of Chongqing Medical University.
Osteofibrous dysplasia (OFD) is a rare disease that may lead to tibial lesions. Currently, no gold standard method exists for the treatment of OFD. Recurrence is the most severe complication in OFD.
View Article and Find Full Text PDFOsteofibrous Dysplasia of Humerus: An Unusual Presentation of a Rare Lesion.
J Hand Microsurg
March 2024
Department of Orthopaedics & Spine Surgery, Ganga Hospital, Coimbatore, Tamil Nadu, India.
Recurrent Adamantinoma With Fibrous Dysplasia-like Feature.
Clin Pathol
April 2024
Department of Pathology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
Adamantinoma (AD) is a rare, slow-growing primary malignant bone tumor characterized by a biphasic morphology of clusters of epithelial cells and spindle cell osteofibrous components. A strong relationship between AD and osteofibrous dysplasia (OFD) has been proposed, while fibrous dysplasia (FD) has been rarely associated with AD. We present an AD case that was followed and histologically evaluated 3 times over 6 years with different morphological patterns.
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